Yesung Cho, Ji Hwan Park, Chan Il Kim, Hyewon Kim, Honglan Li, Yumin Lee, Geongyu Lee, Sujeong Hong 等 31 位作者
Outcome informed AI can localize prognostically relevant regions in digital pathology, but directly characterizing the molecular basis of these spatial predictions remains challenging. Here, we developed an outcome informed, AI-guided deep visual proteomics framework that uses recurrence-risk heatmaps to guide physical tissue sampling and mass spectrometry-based spatial proteomics in triple-negative breast cancer (TNBC). In 156 patients, high- and low-risk regions coexisted within the tumor compartment and showed distinct nuclear and architectural features, indicating intratumoral variation beyond broad tissue identity. Guided by these maps, we physically isolated and profiled 46 AI-defined high- and low-risk tumor regions from two recurrent cases. High-risk regions were enriched for mitotic programs, whereas low-risk regions showed immune- and antigen-presentation-associated programs. We used proteins that consistently differed between high- and low-risk regions to construct a 13-protein composite. The composite showed a significant effect to discriminate highly recurrent patients from less recurrent patients in an expanded TNBC cohort, while the corresponding transcript-based score showed a similar trend in METABRIC. Integrating the protein composite with the H&E-derived risk score improved out-of-bag discrimination, increasing the C-index from 0.679 to 0.739 and the 5-year time-dependent AUC from 0.675 to 0.770. These findings establish outcome-informed H&E risk maps as spatial guides for molecular discovery, extending prognostic AI from prediction toward direct biological interrogation of recurrence-associated tissue states.
Suyoung Bae Sung Kyun Kwan University, CheolWon Na Sungkyunkwan University, Jaehoon Lee Sung Kyun Kwan University, Yumin Lee Sung Kyun Kwan University, YunSeok Choi SungKyunKwan University, Jee-Hyong Lee Sungkyunkwan University
As Large Language Models (LLMs) have become capable of generating long and descriptive code summaries, accurate and reliable evaluation of factual consistency has become a critical challenge. However, previous evaluation methods are primarily designed for short summaries of isolated code snippets. Consequently, they struggle to provide fine-grained evaluation of multi-sentence functionalities and fail to accurately assess dependency context commonly found in real-world code summaries.To address this, we propose ReFEree, a reference-free and fine-grained method for evaluating factual consistency in real-world code summaries. We define factual inconsistency criteria specific to code summaries and evaluate them at the segment level using these criteria along with dependency information. These segment-level results are then aggregated into a fine-grained score. We construct a code summarization benchmark with human-annotated factual consistency labels. The evaluation results demonstrate that ReFEree achieves the highest correlation with human judgment among 13 baselines, improving 15-18% over the previous state-of-the-art. Our code and data are available at https://github.com/bsy99615/ReFEree.git.
尚无 AI 解读，展示原文摘要
cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表