Yulong Li, Rong Xia, Yuxuan Zhang, Jianxu Chen, Xiwei Liu, Haochen Xue, Maosheng Li, Yuhang Liu 等 15 位作者
We introduce DoAtlas-2, a foundation for self-evolving causal biomedical discovery that organizes knowledge around causal mechanisms and advances through external evidence from human populations. DoAtlas-2 integrates 771 research resources covering more than 720,000 participants in 48 countries, from longitudinal clinical phenotypes, medical imaging, and continuous physiological signals to eight molecular layers, together with an evidence network of approximately 4.7 million literature-derived records over 93,566 concepts and 149,383 candidate causal relations. DoAtlas-2 autonomously formulates research questions from evidence gaps and unresolved mechanisms, prespecifies their causal designs, and generates validated analyses. Supporting, challenging, and unresolved results continuously revise mechanistic interpretations, the causal evidence state, and the discovery frontier, so that DoAtlas-2 self-evolves within a closed loop of hypothesis generation, empirical testing, and renewed discovery. DoAtlas-2 has systematically evaluated 2,031 research questions. In the Human Phenotype Project (HPP), it formulated 4,014 candidate pathway questions across vascular, early-glycemic, and hepatic-metabolic systems, and screening of the first 1,079 yielded statistical support for 756. Representative studies identify blood pressure as a convergence node linking adiposity, hepatic, and lipid phenotypes to vascular outcomes, and show that an adiposity-inflammation-blood-pressure pathway is largely attenuated by joint adjustment for body mass index (BMI) and smoking. The discovered vascular network constitutes a completely interpretable predictive foundation, admitting exact attribution of every prediction and closed-form mediation effects. DoAtlas-2 thereby unifies causal mechanism discovery, population-evidence testing, and interpretable prediction within one continuously evolving foundation.
Multi-teacher on-policy distillation consolidates expert capabilities by supervising student-generated trajectories, whereas task arithmetic offers a training-free alternative through linear parameter combinations. We view the linear combination of student and expert parameters as a single differentiable model and propose P$^2$-MOPD, which jointly optimizes the mixing coefficients and the student weights under the same on-policy distillation objective. Unlike task arithmetic, which stays within the span of the frozen student and expert parameters for any choice of merging coefficients, P$^2$-MOPD keeps the student trainable, so the experts act as parameter priors without confining it to this span. Across four domains at 1.7B and 4B scales, P$^2$-MOPD achieves faster and more balanced recovery than MOPD from the same initialization, surpassing its final average recovery in half the training steps. At the end of training, our 1.7B model reaches 94.7% average recovery, versus 80.9% for MOPD.
Biao Wu, Yutong Xie Mohamed bin Zayed University of Artificial Intelligence, Zeyu Zhang Australian National University, Vu Minh Hieu Phan, Qi Chen Adelaide University, Ling Chen University of Technology Sydney, Qi Wu The University of Adelaide
Vision-and-language pretraining (VLP) in medicine leverages contrastive learning on image–text pairs, often enhanced with masked modeling. However, existing methods face two challenges: difficulty reconstructing key pathological features due to limited data, and reliance on either paired or image-only datasets without combining both. To address this, we propose MMCLIP (Masked Medical Contrastive Language–Image Pre-training), which introduces two modules: AttMIM: Masks image features highly correlated with text to improve reconstruction of fine medical details. EntMLM: Masks key medical entities in text and reconstructs them using visual cues. Furthermore, MMCLIP incorporates unpaired data through disease-kind prompts, achieving state-of-the-art performance in zero-shot and fine-tuning across five benchmarks.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表