We present GO-CBED, a goal-oriented Bayesian framework for sequential causal experimental design. Unlike conventional approaches that select interventions aimed at inferring the full causal model, GO-CBED directly maximizes the expected information gain (EIG) on user-specified causal quantities of interest, enabling more targeted and efficient experimentation. The framework is both non-myopic, optimizing over entire intervention sequences, and goal-oriented, targeting only model aspects relevant to the causal query. To address the intractability of exact EIG computation, we introduce a variational lower bound estimator, optimized jointly through a transformer-based policy network and normalizing flow-based variational posteriors. The resulting policy enables real-time decision-making via an amortized network. We demonstrate that GO-CBED consistently outperforms existing baselines across various causal reasoning and discovery tasks-including synthetic structural causal models and semi-synthetic gene regulatory networks-particularly in settings with limited experimental budgets and complex causal mechanisms. Our results highlight the benefits of aligning experimental design objectives with specific research goals and of forward-looking sequential planning.
Foundation-model predictors of perturbation response are evaluated primarily by aggregate accuracy. Using their predictions to prioritize experiments requires assessing each prediction's reliability. We audit the state-transition (ST) decoder used in STATE across three encoders (SE-600M, scGPT, and Tahoe-x1) and four cell lines under CRISPRi. The decoder's first attention layer has a low-rank output. Projecting this output onto 4-32 fixed directions estimated from training activations preserves mean per-perturbation Pearson delta correlation (PDC). This low-rank attention bottleneck bounds the decoder's reliability by distance to training responses: PDC declines as the cosine distance from a perturbation's observed response to its nearest training response increases. We propose predicted-NN-distance, the cosine distance from a predicted response to its nearest training response, as a per-prediction confidence score. The score has a mean absolute Spearman correlation of 0.81 with PDC, close to the 0.88 obtained with the observed response. Thresholds calibrated on this score transfer across encoders and cell lines, and the score remains predictive of PDC for drug perturbations.
Shuo Yang, Zheyu Zhang Technical University of Munich, Bardh Prenkaj, Gjergji Kasneci Technische Universität München and University of Tuebingen
Generating high-fidelity synthetic tabular data remains a critical challenge for enhancing data availability in privacy-sensitive and low-resource domains. Recent approaches leverage LLMs by representing table rows as sequences, yet suffer from two fundamental limitations: (1) they model feature dependencies densely, introducing spurious correlations; and (2) they assume static relationships between features, ignoring how these dependencies vary with feature values. To overcome these limitations, we introduce SAGE (Sparse Adaptive Guidance), a novel LLM-based generation framework that enforces sparse and dynamic dependency guidance. SAGE discretizes features into value-aware pseudo-features and constructs a mutual information-based sparse dependency graph. This graph adaptively guides generation through explicit context selection or implicit logit correction, enabling LLMs to focus on truly relevant information during synthesis. Our extensive experiments across six datasets and multiple tasks reveal that SAGE not only improves data fidelity and downstream utility, boosting F1 scores by 10% compared to previous LLM-based methods, but also reduces policy violations by one point. These results highlight the importance of adaptive structure in tabular data generation and provide new insights into context-sensitive control of LLMs.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Chenchen Yuan Technical University of Munich, Zheyu Zhang Technical University of Munich, Gjergji Kasneci Technische Universität München and University of Tuebingen
Large language models often display heterogeneous moral preferences across settings. We study inference-time steering toward a desired ethical framework while preserving general competence. We present Convergent-Divergent Routing, which traces and edits minimal branch points inside transformer blocks where ethical-framework-related pathways first converge and then diverge. Gating non-target branches at these loci blocks the downstream propagation while leaving upstream computations intact. We find that this intervention alone increases targeted ethical-framework reasoning. To achieve fine-grained control, we adapt Common Spatial Patterns to the residual stream and extract, for each branch-point layer, a pair of directions that discriminate between utilitarian and deontological frameworks. We then introduce Dual Logit Calibration, a closed-form, minimum-\ell_2-norm update that moves the residual within this two-dimensional subspace so the resulting directional projections align with user-specified preference weights. Experiments on real-life moral dilemmas show that our method reliably achieves preference calibration and largely preserves general capabilities, outperforming recent baselines while providing an interpretable mechanism.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表