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Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.

Large language models have made rapid progress in agentic reasoning and tool use, raising expectations for agents that can take over realistic productivity work from humans. However, current agents still struggle to finish such tasks, where success requires following long-horizon professional workflows, understanding heterogeneous file contexts, and producing usable deliverables under fine-grained requirements. A key bottleneck is the lack of scalable post-training data that reflects real work intent, authentic file environments, and deliverable-level evaluation. To close this gap, we introduce Agent-R$^2$, a $\textbf{r}$eal-source data synthesis framework that scales training data for $\textbf{r}$ealistic productivity work. Instead of relying on manually specified workflows or LLM-generated files, Agent-R$^2$ grounds synthesis throughout the pipeline in real occupational seeds, corpus-derived workflow evidence, and authentic web-sourced files. From 10k web-corpus candidates, Agent-R$^2$ distills 4k task instances that pair real multi-format attachments with fine-grained, deliverable-level rubrics. On this data, we train Agent-R$^2$-4B via supervised fine-tuning and rubric-based reinforcement learning, improving both end-to-end productivity performance and file-grounded reasoning. Trained on only 4k instances, Agent-R$^2$-4B surpasses Qwen3-235B-A22B-Thinking-2507 on both GDPval (51.0$\%$ vs. 48.0$\%$) and OfficeQA (14.8$\%$ vs. 13.8$\%$). Further analysis shows that Agent-R$^2$ mitigates shortcut behavior, where agents produce superficially plausible deliverables before sufficiently grounding, constructing, or verifying them, while promoting sustained exploration.

Robot manipulation in everyday environments inherently involves substantial tool usage. Seemingly simple household tasks, such as cooking pan-fried tofu, require forceful cutting, delicate brushing, and precise placement using different tools under contact-rich interaction. Thus, the ability to autonomously swap and use task-appropriate tools is important for tool-centric manipulation. We introduce SwapBot, a modular, tool-centric end effector system featuring low-cost adapters that quickly convert common household tools into robot end effectors. Rather than pursuing a single universal gripper, SwapBot adopts a unified design principle that combines a fixed robot-side coupling interface with low-cost, tool-side adapters, enabling compatibility with diverse tools, including articulated ones, and multiple robot platforms. Each adapter integrates compact tactile sensors, supports fast autonomous swapping, and interfaces with an intuitive teleoperation system for efficient demonstration collection. User studies show that, during teleoperation, SwapBot reduces task completion time and operator workload. Using collected demonstrations on the robot, we train imitation learning policies to successfully perform tool-centric tasks like cooking tofu, stirring salad, flipping meat. Our ablation study shows that using tactile-augmented demonstrations improves policy performance across contact-rich skills, increasing success rates by 15 to 25 percentage points over RGB-only policies. These results highlight modular, tactile-equipped tools as a practical and extensible pathway toward robust and capable robot manipulation. Project website https://personalrobotics.github.io/SwapBot.