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版本更新 · v2arXiv:2610.09841

ORCA: Hunting Compositional Failures in Text-to-Image Diffusion

Arshia Hemmat, Amirhossein Vahidi, Amitis Shidani, Mohammad Vali Sanian, Hesam Asadollahzadeh, Aryan Yazdan Parast, Mohammad Lotfollahi

原文摘要

Text-to-image diffusion models fail predictably on compositional prompts: attributes bind to the wrong objects, spatial relations invert, and multi-object scenes lose count. Recent architectures already augment CLIP with a T5 encoder precisely because CLIP's contrastive embedding loses compositional structure, yet these failures persist. We argue the binding problem is therefore not one of missing information but of misaligned information: a text encoder preserves compositional structure, but in a representation space shaped by language modelling rather than vision, and the denoising objective does not directly reward aligning the two. We show this correspondence can be supplied as an explicit training signal, that the relevant cross-modal information is concentrated in a low-rank subspace of self-supervised visual features, and that supplying it can be folded into diffusion training as a single auxiliary loss. Our method, ORCA (Orthogonal Residual Compositional Alignment), aligns the latent of a diffusion transformer with a low-rank target derived from a frozen visual encoder, through a predictor whose orthogonal basis is parameterised by a learned residual between T5 and CLIP embeddings, which provides a prompt-dependent signal for selecting the visual readout subspace. We prove that the cross-modal information recoverable at a given rank is bounded by the spectral mass of the visual encoder's covariance in the top components. Across three diffusion-transformer backbones (DiT-B/2, DiT-L/2, U-ViT-L), ORCA improves FID and GenEval over both vanilla and REPA baselines at zero inference-time cost; on DiT-L/2 it reaches FID 16.65 and GenEval 0.291 at 200K steps, exceeding the strongest 400K baseline at half the training cost, with the largest gains concentrated on attribute binding, spatial relations, and multi-object prompts.

cs.CV · cs.LG

版本更新 · v3arXiv:2511.14613

3D-Guided Scalable Flow Matching for Generating Volumetric Tissue Spatial Transcriptomics from Serial Histology

Mohammad Vali Sanian, Arshia Hemmat, Amirhossein Vahidi, Jonas Maaskola, Jimmy Tsz Hang Lee, Martin Prete, Stanislaw Makarchuk, Yeliz Demirci 等 13 位作者

原文摘要

A 3D transcriptomic profile of a tissue can give a holistic view of its organization in health and disease, but spatial transcriptomics (ST) is costly, so usually only some serial sections are profiled, while H&E is available for all. Most methods that infer ST from histology treat each section independently and ignore 3D structure, while existing 3D-aware approaches are not generative and do not scale well. We present Holographic Tissue Expression Inpainting and Analysis (HoloTea), a 3D-aware flow-matching framework that imputes spot-level gene expression on an unprofiled section from its H&E and the measured expression of adjacent profiled sections. Our key idea is to take the measured expression at the same registered position on neighboring sections and feed this cross-section context to the flow model through a lightweight ControlNet, so that predictions follow anatomical continuity along z. To capture the discrete, zero-inflated nature of counts, the flow starts from a learned zero-inflated negative binomial (ZINB) prior that, on an unprofiled section, is predicted from the measured expression of the nearest profiled section. A global attention block with a small set of inducing tokens adds whole-slide context at a cost linear in the number of spots, so training and inference scale to large 3D ST datasets. Across three ST datasets spanning different tissue types and resolutions, HoloTea consistently improves 3D expression accuracy and generalization compared to 2D and 3D baselines. We envision HoloTea advancing the creation of accurate 3D virtual tissues, ultimately accelerating biomarker discovery and deepening our understanding of disease. Code is available at https://github.com/Lotfollahi-lab/HoloTea.

cs.CV