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新论文 · v1arXiv:2611.15618

Data augmentation for the generalizability and transportability of fairness in a clinical heart failure algorithm

I. Elizabeth Kumar, Sherri Rose

原文摘要

Synthetic data augmentation has been proposed as a way to artificially supplement clinical datasets to address fairness concerns in downstream classification algorithms. This approach is closely related to upweighting or upsampling methods employed for the problem of class imbalance, which have shown mixed empirical results in practice. Synthetic data augmentation also runs the risk of overfitting to the noise present in subgroups with relatively small sample sizes, raising both generalizability and transportability concerns. We present an empirical evaluation of synthetic data augmentation for fairness in tabular data using simulation studies as well as a real-world application of in-hospital mortality classification for heart failure patients in two distinct data samples. We implement upsampling and upweighting methods as benchmarks for the implicit fairness objective of synthetic data augmentation. Our results suggest that the fairness impacts of data augmentation are sensitive to the design of the downstream algorithm as well as the deployment context and its similarity to the training data. It is crucial that studies making generalizability and transportability claims should provide empirical support for these assertions.

stat.AP · cs.CY · stat.ME

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.13564

A Concept-Based Interpretable Framework for Clinical Text-based Prediction via Token-Concept Attention without Concept Supervision

Jifan Gao, Junjie Hu, John Caskey, Madeline Oguss, Simona Cristea, Anoop Mayampurath, Matthew Churpek, Majid Afshar 等 9 位作者

原文摘要

Objective: Concept-based interpretation has emerged as a promising approach for explaining blackbox models using human-understandable, high-level concepts. However, most existing methods require annotated concept labels to train the model to identify concepts in the input, and obtaining such annotations in clinical text is often expensive. This study aims to enable concept-based interpretation for language models without concept supervision on clinical prediction tasks. Methods: We propose a novel framework that enables concept-based interpretation without concept supervision through a tailored cross-attention bottleneck. Clinical text and the text descriptions of medical concepts are first tokenized and embedded by a pretrained language model. A cross-attention module then estimates the presence of each concept for each text token, producing concept relevance scores that capture how concepts are involved throughout the note. These scores are pooled and used in a linear prediction layer to model clinical outcomes in an interpretable manner. Results: The performance of the proposed framework was compared against blackbox models across two tasks: chest trauma severity stratification using a private dataset and an in-hospital mortality prediction task using the publicly available MIMIC-III dataset. The proposed framework achieved AUROC values within 0.02 of the corresponding blackbox models. The framework also enabled cohort- and patient-level interpretation, capturing the overall concept importance across the cohort and patient-specific concept contributions. Conclusion: Our proposed framework realizes concept-based interpretation without requiring ground-truth concept presence labels. It improves the transparency of clinical text predictions while maintaining strong performance in clinical prediction tasks.

cs.CL · cs.AI

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arXiv ↗PDF ↗
版本更新 · v4arXiv:2603.27397

Benchmarking Quantum Computers via Protocols, Comparing Superconducting and Ion-Trap Quantum Technology

Nitay Mayo, Tal Mor, Yossi Weinstein

原文摘要

Both Superconducting and Ion-Trap are leading quantum architectures common in the current landscape of the quantum computing field, each with distinct characteristics and operational constraints. Understanding and measuring the underlying $\underline{\text{quantumness}}$ of these devices is essential for assessing their readiness for practical applications and guiding future progress and research. Building on earlier work (Meirom, Mor and Weinstein Arxiv 2505.12441), we utilize a benchmarking strategy applicable for comparing these two architectures by measuring "quantumness" directly on optimal sub-chips. Distinct from existing metrics, our approach employs rigorous binary fidelity thresholds derived from the classical limits of state transfer. This enables us to definitively establish quantum advantage of a designated sub-region. Here we apply this quality assurance methodology to platforms from both technologies. This comparison provides a protocol-based evaluation of quantumness advantage, revealing not only the strengths and weaknesses of each tested chip and its sub-chips but also offering a common language for their assessment. By abstracting away technical differences in the final result, we demonstrate a benchmarking strategy that bridges the gap between disparate quantum-circuit technologies, enabling fair performance comparisons and establishing a critical foundation for evaluating future claims of quantum advantage. We encourage other companies to emulate the independent qubit availability and the fair pricing, as do IBM and AQT, which allow researchers to perform such assessments. In the discussion section, we consider an important future direction of using "benchmarking via protocols" also for fault-tolerant quantum computing with logical qubits.

quant-ph · cs.DC · cs.ET

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.09102

COMBIO: Automated Discovery of a Compact Composite Biomarker from Routine Laboratory Panels

Tomer D. Meirman, Lior S. Rokach, Bracha Shapira, Seffi Cohen, Noa Dagan

原文摘要

Machine-learning models based on routine laboratory panels can predict outcomes but can be difficult to interpret and operationalize. We present COMBIO, an automated pipeline that distils such a model into a compact closed-form biomarker. The composite is a product of laboratory measurements raised to integer powers from minus two to two. The sign of each exponent indicates whether higher values of the corresponding measurement increase or decrease the composite. Shapley additive explanation values from the gradient-boosted reference model rank five candidate measurements and guide eligible exponent signs. An exhaustive search over small integer exponents selects the formula on an inner validation set, before evaluation on the reserved test set. We evaluated COMBIO across six tasks: three National Health and Nutrition Examination Survey outcomes, liver-disease classification in the Indian Liver Patient Dataset, and Medical Information Mart for Intensive Care IV in-hospital mortality and sepsis case-finding, with external evaluation in the eICU Collaborative Research Database for the two hospital tasks. Across the six test sets, COMBIO's area under the receiver operating characteristic curve differed by at most 0.03 from logistic regression using the five candidate laboratory measurements. The hospital mortality composite had an area under the curve of 0.698 in the external database. A version restricted to widely available measurements in the source hospital database achieved an area under the curve of 0.786 in a cohort covering 92% of admissions. The multiplicative representation provides compactness rather than additional accuracy, and local validation and recalibration are required before clinical use.

cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2608.02663

Variable-aware representation, not relation typing, explains the performance of an event-graph model for ICU mortality prediction: temporal and external validation

Mohammad Nasir Uddin, Eklachur Rahman Bhuiyan, Rahnuma Tabassum Orpita

原文摘要

Event-graph neural networks represent intensive care unit (ICU) records as typed entities linked by timestamped observations, and their gains are often attributed to relation-specific message passing. We tested which components matter once leakage is removed and validation is temporal and external. In 31,142 first ICU stays of at least 48 hours in the Medical Information Mart for Intensive Care IV (MIMIC-IV), models predicting post-48-hour in-hospital mortality were developed on 2008-2016 stays, tested on held-out 2008-2016 stays and on 2017-2019 and 2020-2022 stays, and applied without retraining to 54,696 stays from 205 hospitals in the eICU Collaborative Research Database. A leak in a previous version, total ICU length of stay used as an input, was removed. A variable-aware representation (a learned embedding of each node's variable plus per-variable normalisation) raised the mean single-model area under the receiver operating characteristic curve (AUROC) from 0.846 to 0.896 in 2020-2022 and from 0.699 to 0.809 externally. With it, relation-specific and shared (relation-collapsed) message passing differed by less than 0.005 AUROC in every test set, within a +/-0.01 equivalence margin, although relation typing had appeared beneficial without it. The revised model's AUROC was 0.878-0.900 across MIMIC-IV periods, 0.15-0.19 above three severity scores and 0.007-0.011 below gradient boosting. Externally, the five-model average reached AUROC 0.825 versus 0.788 for the Acute Physiology and Chronic Health Evaluation (APACHE) IVa score on the 48,184 stays with an APACHE prediction. In this model, representation mattered more than message-passing architecture.

cs.LG · cs.AI

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.05222

基于AUC的临床预测AI公平性指标

Fairness Metrics based on the AUC in Clinical Predictive AI

João Matos, Ben Van Calster, Richard D. Riley, Paula Dhiman, Gary S. Collins

AI 速读 基于摘要

系统梳理并批判性评估八种基于AUC的临床预测模型公平性指标，建议以AUC矩阵报告为主、谨慎选用公平性指标。

cs.LG · cs.AI

arXiv ↗PDF ↗
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Fairness evaluation of clinical prediction models for binary outcomes often involves fairness metrics that compare the area under the receiver operating characteristic curve (AUC, or c-statistic) across subgroups. However, the AUC has been shown to be a non-collapsible metric, meaning that its subgroup specific and overall values are not directly comparable as often implicitly assumed. This raises important questions about how existing AUC-based fairness metrics should be used and interpreted. We examine eight AUC-based fairness metrics proposed in the literature, including: within-group AUC parity; cross-group AUC (xAUC) parity; gap-to-overall AUC; equity-scaled AUC; minimum-based metrics; $\mathrm{xAUC}^1$; $\mathrm{xAUC}^0$; and $\mathrm{xAUC}^1$ or $\mathrm{xAUC}^0$ parity. We characterise their estimands, relate them to the decomposition of overall AUC (into within- and cross-group components), and critically appraise them. We then illustrate their behaviour using simulations based on the EuroSCORE II, a clinical prediction model for in-hospital mortality. We recommend reporting an AUC matrix, containing the overall AUC and all within- and cross-group AUC components, alongside population characteristics. When fairness metrics are needed, we recommend reporting the within-group AUC parity, with cross-group AUC parity providing supplementary information but requiring caution due to its potential conflict with calibration. Metrics involving $\mathrm{xAUC}^1$ and $\mathrm{xAUC}^0$ have merit, summarising within- and cross-group AUCs into single values, but their interpretation is non-trivial, and they should be used with caution. Gap-to-overall AUC, equity-scaled AUC, and minimum-based metrics compare quantities that should not be compared and it is unclear how to operationalise them, making them not fit for purpose and generally not recommended.

版本更新 · v2arXiv:2509.19577

MAGIC: Multi-task Gaussian process for joint imputation and classification in healthcare time series

Dohyun Ku, Catherine D. Chong, Visar Berisha, Todd J. Schwedt, Jing Li

原文摘要

Time series analysis has emerged as an important tool for improving patient diagnosis and management in healthcare applications. However, these applications commonly face two critical challenges: time misalignment and data sparsity. Traditional approaches address these issues through a two-step process of imputation followed by prediction. We propose MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification), a novel unified framework that simultaneously performs class-informed missing value imputation and label prediction within a hierarchical multi-task Gaussian process coupled with functional logistic regression. To handle intractable likelihood components, MAGIC employs Taylor expansion approximations with bounded error analysis, and parameter estimation is performed using EM algorithm with block coordinate optimization supported by convergence analysis. We validate MAGIC through two healthcare applications: prediction of post-traumatic headache improvement following mild traumatic brain injury and prediction of in-hospital mortality within 48 hours after ICU admission. In both applications, MAGIC achieves superior predictive accuracy compared to existing methods. The ability to generate real-time and accurate predictions with limited samples facilitates early clinical assessment and treatment planning, enabling healthcare providers to make more informed treatment decisions.

stat.ML · cs.LG

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.36535

A generalist policy for muscle-driven control across individual musculoskeletal models

Bozhao Wang, Yinglei Zhu, Zhengqing Li, Zhiyuan Zhang, Weiming Kang, Yiheng He, XinJun Liu, Senhao Hou 等 10 位作者

原文摘要

Differences in musculoskeletal morphology challenge policy reuse across individual models. Here we present MyoAcross, a framework that combines individual musculoskeletal model construction, morphology-conditioned policy learning and virtual model augmentation to enable muscle-driven reference-motion tracking without individual fine-tuning. Across 31 held-out individual models, MyoAcross achieves 99.24% completion and reduces tracking error by 22.60% relative to an unconditioned multilayer perceptron. Policy reuse extends to models of 22 held-out individuals constructed from single-image shape estimates, measured height and body mass, and, with asymmetry augmentation, to models with unilateral lower-limb shortening. Comparisons with measurements from 120 additional individuals show agreement in vertical ground reaction force waveforms and channel-dependent agreement between simulated muscle activations and electromyography. These results establish a common control framework for comparative simulations of movement across individual musculoskeletal models.

cs.RO

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.36006

MedJev: Evaluating Zero-Shot System-One Decision Making in Medicine

Simon A. Lee, Jiahang Sha, Moonseong Jeong, Yunbei Pan, Jeffrey N. Chiang

原文摘要

System One decision models such as Jev answer structured questions in a single forward pass without generating text, offering fast and computationally efficient clinical decision support. We evaluate MedJev, an open System One model that runs locally on a laptop, across ten medical benchmarks spanning medical knowledge, diagnosis, and patient level prediction using MIMIC IV and MIMIC IV ED. We compare MedJev against zero shot LLM baselines, published GPT results, and supervised models. MedJev achieves accuracies of 72.5 percent on MedQA, 75.4 percent on USMLE, and 80.1 percent on NEJM, approaching published GPT 4 performance while maintaining well calibrated confidence estimates (ECE 0.028 to 0.063). On patient level tasks, MedJev achieves an AUROC of 0.926 for In Hospital Mortality, exceeding XGBoost (0.902), but underperforms supervised models on operational outcomes such as ED Triage Admission (0.745 vs. 0.809). Patient level predictions also exhibit substantial miscalibration (In Hospital Mortality ECE 0.286). We introduce a lightweight, two parameter recalibration method that adapts predictions to local patient populations using 50 to 200 labeled examples, reducing ECE to 0.007. Our findings establish open System One models as a promising zero shot baseline for medical AI, combining competitive predictive performance with low computational cost and efficient local calibration. We release our code and evaluation harness to support future research.

cs.CL · cs.AI · cs.LG

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arXiv ↗PDF ↗