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统计口径与数据新鲜度

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新论文 · v1arXiv:2611.11140

SurgWorld: Learning Surgical Representations Beyond Observation via Latent Prediction

Jingkun Yue, Pengxiang Wang, Siqi Zhang, Zinan Jia, Yiyao Zhang, Huihuan Xu, Yichang Hao, Xiaohong Liu 等 10 位作者

原文摘要

Surgical procedures are inherently partially observable, requiring surgeons to continuously infer evolving anatomical dynamics and future surgical states beyond the current observation. However, existing self-supervised learning methods primarily learn from observed surgical videos through masked reconstruction or predicting representations within the camera's current field of view, lacking the capability to explicitly model the out-of-sight surgical dynamics. Inspired by latent predictive world models, we introduce SurgWorld, a video-native, self-supervised framework for surgical representation learning, which treats a specified spatial or temporal shift as a pseudo-action and learns to predict the target latent representation from a partial observation. Specifically, we propose Out-of-Sight Dynamics Modeling (OSDM) as the pretraining objective for predicting representations conditioned on relative spatio-temporal shifts. We further regularize the learned latent dynamics from OSDM with a Geometric Visual Similarity (GVS) objective by aligning patch-level relational structures between predicted and target representations, preserving spatial geometry and local visual coherence for dense perception. These two objectives are integrated through an agglomerative training framework that consolidates complementary supervisory signals from multiple teachers to learn a unified latent representation of surgical dynamics and visual geometry. Extensive transfer learning experiments on 17 surgical benchmarks show that SurgWorld consistently outperforms existing vision foundation models across surgical workflow recognition, fine-grained action understanding, and dense visual perception. We further conduct tailored qualitative and quantitative analyses, demonstrating that SurgWorld effectively captures surgical dynamics beyond the directly observed context through latent prediction.

cs.CV

版本更新 · v2arXiv:2608.19808

FAR-DPO: Feasibility-Aware and Robust Direct Preference Optimization for Cyclic Peptide Design

Guofeng Zhang, Rong Han, Xiaoyu Wang, Zhiyun Li, Zongbo Han, Xiaohong Liu, Guangyu Wang

原文摘要

Cyclic peptides are emerging as promising molecular scaffolds in drug discovery due to their high binding affinity and structural stability. However, extending generative models from linear to cyclic peptide design remains challenging, as cyclization sharply restricts the feasible design space through coupled geometric and biophysical constraints. Moreover, limited training data has led existing approaches to rely largely on zero-shot generation or post hoc filtering, resulting in low yields of feasible designs and limited control over multi-objective trade-offs. To address these limitations, we propose FAR-DPO (Feasibility-Aware and Robust Direct Preference Optimization), an architecture-agnostic framework that steers generative models toward structurally and biophysically feasible cyclic peptide designs, particularly for challenging targets. FAR-DPO integrates feasibility-aware preference construction with difficulty-aware group-robust optimization. Specifically, it constructs within-target preference pairs through feasibility-gated multi-objective dominance and adaptively reweights predefined difficulty groups according to their current preference losses. Under a fixed generation budget, FAR-DPO increases overall success rate on the CPSea benchmark from 46.9% to 57.8% on PepGLAD and from 48.0% to 49.6% on PepFlow. These gains also extend to the hardest target quartile and are accompanied by more favorable best-per-target binding scores. Together, these results demonstrate FAR-DPO's effectiveness in improving feasibility and target-wise robustness.

cs.LG