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arXiv:2611.11644 · v1

MICE: Multi-animal Interaction Context Encoder - A Hierarchical Foundation Model for Mouse Behavior

首次提交 2026-11-09 05:59
版本更新 2026-11-09 05:59
雷达观测 2026-11-10 13:19
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摘要

Quantifying mouse behavior from pose is a foundational tool in neuroscience, ethology, drug discovery, and animal welfare. Self-supervised foundation models are a natural fit, but a foundation model for mouse behavior must handle social behavior - many behaviors that matter (aggression, courtship, mounting, allogrooming) are inherently multi-animal. Existing self-supervised pose models fall short: they encode each animal independently and discard interaction signal, hard-code the animal count, and pretrain one dataset at a time. We introduce MICE (Multi-animal Interaction Context Encoder), a hierarchical foundation model for mouse behavior that pretrains jointly on six mouse-pose corpora spanning one to four mice and 7 to 27 keypoints. MICE combines a hierarchical individual encoder capturing per-mouse kinematics at multiple temporal scales with a Perceiver-style social encoder whose learned latent codebook decouples parameter count from animal count, so a single checkpoint serves any group size without retraining. Across four evaluation protocols spanning six datasets, MICE matches or exceeds prior keypoint-based baselines, and layer-wise probing shows the social stage incrementally improves discriminability beyond the individual encoder. Code, weights, and data are available at https://github.com/eric0708/MICE.

作者备注:NeurIPS 2026 (Spotlight). 25 pages, 4 figures. Code: https://github.com/eric0708/MICE

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v1 · 2026-11-09 05:59 · 最新观测版本

MICE: Multi-animal Interaction Context Encoder - A Hierarchical Foundation Model for Mouse Behavior

Quantifying mouse behavior from pose is a foundational tool in neuroscience, ethology, drug discovery, and animal welfare. Self-supervised foundation models are a natural fit, but a foundation model for mouse behavior must handle social behavior - many behaviors that matter (aggression, courtship, mounting, allogrooming) are inherently multi-animal. Existing self-supervised pose models fall short: they encode each animal independently and discard interaction signal, hard-code the animal count, and pretrain one dataset at a time. We introduce MICE (Multi-animal Interaction Context Encoder), a hierarchical foundation model for mouse behavior that pretrains jointly on six mouse-pose corpora spanning one to four mice and 7 to 27 keypoints. MICE combines a hierarchical individual encoder capturing per-mouse kinematics at multiple temporal scales with a Perceiver-style social encoder whose learned latent codebook decouples parameter count from animal count, so a single checkpoint serves any group size without retraining. Across four evaluation protocols spanning six datasets, MICE matches or exceeds prior keypoint-based baselines, and layer-wise probing shows the social stage incrementally improves discriminability beyond the individual encoder. Code, weights, and data are available at https://github.com/eric0708/MICE.

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