← 研踪 PaperTrailarXiv:2611.13801 · v1
Bridging Graph and Pairwise Learning for Gene Regulatory Network Inference from scRNA-seq Data
首次提交 2026-11-10 17:34
版本更新 2026-11-10 17:34
雷达观测 2026-11-11 11:04
摘要
Motivation: Gene regulatory networks (GRNs) capture the underlying interactions through which transcription factors (TFs) regulate genes. Based on gene expression data, existing GRN inference approaches generally fall into two categories: graph-based methods, which model the GRN as a whole graph, and pairwise-based methods, which decompose the GRN into individual TF-target gene pairs for modeling. However, each approach exhibits limitations that are precisely the strengths of its counterpart. Graph-based methods tend to overfit due to their reliance on a single training graph, whereas pairwise-based methods benefit from abundant TF-target training pairs. In contrast, pairwise-based methods overlook the global topological structure, which is essential for comprehensively capturing regulatory mechanisms. Results: To address these limitations, we propose scGPL, an end-to-end unified framework that jointly models global regulatory topology and local interactions. scGPL extracts macro-level features from the global regulatory graph and introduces a dynamic, importance-guided subgraph sampling mechanism to capture fine-grained local dependencies. By fusing global representations with subgraph-enhanced local features, our framework bridges the gap between the two paradigms, incorporating essential whole-graph topological dependencies while retaining the data abundance advantage of pairwise methods. Extensive experiments on seven benchmark datasets demonstrate that scGPL consistently achieves state-of-the-art performance, with up to 13.7% improvement over the strongest baseline, validating the effectiveness of our integrative design. Availability and implementation: The source code is maintained on GitHub (https://github.com/talent-hang/scGPL), and the datasets and versioned releases are archived at https://doi.org/10.5281/zenodo.21608485 for reproducibility.
作者备注：Accepted to Bioinformatics
观测到的版本
相邻记录可能跳过中间版本；首次发现 v2 及以上也会标为版本更新。
v1 · 2026-11-10 17:34 · 最新观测版本
Bridging Graph and Pairwise Learning for Gene Regulatory Network Inference from scRNA-seq Data
Motivation: Gene regulatory networks (GRNs) capture the underlying interactions through which transcription factors (TFs) regulate genes. Based on gene expression data, existing GRN inference approaches generally fall into two categories: graph-based methods, which model the GRN as a whole graph, and pairwise-based methods, which decompose the GRN into individual TF-target gene pairs for modeling. However, each approach exhibits limitations that are precisely the strengths of its counterpart. Graph-based methods tend to overfit due to their reliance on a single training graph, whereas pairwise-based methods benefit from abundant TF-target training pairs. In contrast, pairwise-based methods overlook the global topological structure, which is essential for comprehensively capturing regulatory mechanisms. Results: To address these limitations, we propose scGPL, an end-to-end unified framework that jointly models global regulatory topology and local interactions. scGPL extracts macro-level features from the global regulatory graph and introduces a dynamic, importance-guided subgraph sampling mechanism to capture fine-grained local dependencies. By fusing global representations with subgraph-enhanced local features, our framework bridges the gap between the two paradigms, incorporating essential whole-graph topological dependencies while retaining the data abundance advantage of pairwise methods. Extensive experiments on seven benchmark datasets demonstrate that scGPL consistently achieves state-of-the-art performance, with up to 13.7% improvement over the strongest baseline, validating the effectiveness of our integrative design. Availability and implementation: The source code is maintained on GitHub (https://github.com/talent-hang/scGPL), and the datasets and versioned releases are archived at https://doi.org/10.5281/zenodo.21608485 for reproducibility.
查看此版本解读 →查看此版本原文 ↗