← 研踪 PaperTrailarXiv:2611.14338 · v1
An Information-Theoretic Perspective on Regulatory T Cell Localization as an IL-2 Interference Filter
信息论视角下调节性T细胞定位作为IL-2干扰滤波器
首次提交 2026-11-11 01:03
版本更新 2026-11-11 01:03
雷达观测 2026-11-11 13:07
摘要
Diffusible signals enable communication between immune cells but can also create interference between nearby activation sites. In lymph nodes, effector T cells (Teff) concentrate around antigen-presenting cells (APCs), release interleukin-2 (IL-2) following antigen recognition, and sense IL-2 through cell-surface receptors. Experiments show high-uptake regulatory T cells (Treg) clustered around IL-2-producing cells. However, it is unclear how strongly responses at neighboring activation sites are coupled through diffusible IL-2, and how this coupling is influenced by the spatial organization of Treg acting as IL-2 sinks. We interpret two neighboring sites as a molecular communication system and study the effect of clustering using a three-dimensional IL-2 field coupled to T cell population dynamics. Across a broad parameter sweep, clustering Treg produces a larger mean reduction in neighboring-site interference than adding dispersed Treg. Compared with no Treg, clustered Treg suppress interference while largely preserving the strong local response with corresponding consequences for population expansion and survival. Information-theoretic analysis shows improved discrimination between weak and strong local sources at short separation, whereas at larger separation clustering primarily reduces the remaining estimated neighboring-source information. These findings support a spatial-filtering role for Treg clustering in maintaining locally informative immune responses.
作者备注：6 pages, 6 figures; submitted to IEEE ICC for review
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v1 · 2026-11-11 01:03 · 最新观测版本
An Information-Theoretic Perspective on Regulatory T Cell Localization as an IL-2 Interference Filter
Diffusible signals enable communication between immune cells but can also create interference between nearby activation sites. In lymph nodes, effector T cells (Teff) concentrate around antigen-presenting cells (APCs), release interleukin-2 (IL-2) following antigen recognition, and sense IL-2 through cell-surface receptors. Experiments show high-uptake regulatory T cells (Treg) clustered around IL-2-producing cells. However, it is unclear how strongly responses at neighboring activation sites are coupled through diffusible IL-2, and how this coupling is influenced by the spatial organization of Treg acting as IL-2 sinks. We interpret two neighboring sites as a molecular communication system and study the effect of clustering using a three-dimensional IL-2 field coupled to T cell population dynamics. Across a broad parameter sweep, clustering Treg produces a larger mean reduction in neighboring-site interference than adding dispersed Treg. Compared with no Treg, clustered Treg suppress interference while largely preserving the strong local response with corresponding consequences for population expansion and survival. Information-theoretic analysis shows improved discrimination between weak and strong local sources at short separation, whereas at larger separation clustering primarily reduces the remaining estimated neighboring-source information. These findings support a spatial-filtering role for Treg clustering in maintaining locally informative immune responses.
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