← 研踪 PaperTrailCVF · CVPR 2026:cvf:9d8d37d497769d6892c159aeaa82900a · 记录 #1
cryoSENSE: Compressive Sensing Enables High-throughput Microscopy with Sparse and Generative Priors on the Protein Cryo-EM Image Manifold
来源日期（仅到年份） 2026
来源记录日期 2026
雷达观测 2026-11-05 00:37
摘要
Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining practical throughput. We introduce cryoSENSE, the computational realization of a hardware-software co-designed framework for compressive cryo-EM sensing and acquisition. We show that cryo-EM images of proteins lie on low-dimensional manifolds that can be independently represented using sparse priors in predefined bases and generative priors captured by a denoising diffusion model. cryoSENSE leverages these low-dimensional manifolds to enable faithful image reconstruction from spatial and Fourier-domain undersampled measurements while preserving downstream structural resolution. In experiments, cryoSENSE increases acquisition throughput by up to 2.5xwhile retaining the original 3D resolution, offering controllable trade-offs between the number of masked measurements and the level of downsampling. Sparse priors favor faithful reconstruction from Fourier-domain measurements and moderate compression, whereas generative diffusion priors achieve accurate recovery from pixel-domain measurements and more severe undersampling.
论文发现出处
这些页面提供论文线索，不代表同行评审或质量认证。
观测到的版本
平台记录号代表本站观测到的元数据变化，不是作者修订号。来源日期仅到月份或年份时，按该月或该年首日存档。
记录 #1 · 2026 · 最新观测版本
cryoSENSE: Compressive Sensing Enables High-throughput Microscopy with Sparse and Generative Priors on the Protein Cryo-EM Image Manifold
Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining practical throughput. We introduce cryoSENSE, the computational realization of a hardware-software co-designed framework for compressive cryo-EM sensing and acquisition. We show that cryo-EM images of proteins lie on low-dimensional manifolds that can be independently represented using sparse priors in predefined bases and generative priors captured by a denoising diffusion model. cryoSENSE leverages these low-dimensional manifolds to enable faithful image reconstruction from spatial and Fourier-domain undersampled measurements while preserving downstream structural resolution. In experiments, cryoSENSE increases acquisition throughput by up to 2.5xwhile retaining the original 3D resolution, offering controllable trade-offs between the number of masked measurements and the level of downsampling. Sparse priors favor faithful reconstruction from Fourier-domain measurements and moderate compression, whereas generative diffusion priors achieve accurate recovery from pixel-domain measurements and more severe undersampling.
查看此版本解读 →查看此版本原文 ↗