← 研踪 PaperTrailCVF · CVPR 2026:cvf:b6caa0c3611db0edd3de5bc2a483c6f3 · 记录 #1
CARE: A Molecular-Guided Foundation Model with Adaptive Region Modeling for Whole Slide Image Analysis
Zhang, DiGong, ZhangpengPang, XiaoboLiu, JiashuaiLu, JunboCui, HaoGe, JiusongZeng, ZhiYi, KaiLi, YinghuaLiu, SiYu, TingsongWang, HaoranCrispin-Ortuzar, MireiaYu, WeimiaoLi, ChenGao, Zeyu 来源日期（仅到年份） 2026
来源记录日期 2026
雷达观测 2026-11-02 00:21
摘要
Foundation models have achieved success in computational pathology, demonstrating generalization across histopathology tasks. However, existing models overlook the heterogeneous and non-uniform organization of regions of interest (ROIs) because they rely on natural image backbones not tailored for tissue morphology. Consequently, they fail to capture the coherent tissue architecture beyond patches, limiting interpretability and clinical relevance. To address these challenges, we present Cross-modal Adaptive Region Encoder (CARE), a foundation model for pathology that partitions WSIs into several morphologically relevant regions. Specifically, CARE employs a two-stage pretraining strategy: (1) a self-supervised unimodal pretraining stage that learns morphological representations from 34,277 whole-slide images (WSIs) without segmentation annotations, and (2) a cross-modal alignment stage that leverages RNA and protein profiles to refine the construction and representation of adaptive regions. This molecular guidance enables CARE to identify biologically relevant patterns and generate irregular yet coherent tissue regions, selecting the representative area as ROI. CARE supports a broad range of pathology-related tasks, using either the ROI feature or the slide-level feature obtained by aggregating adaptive regions. Based on only one-tenth of the pretraining data typically used by mainstream foundation models, CARE achieves superior average performance across 33 downstream benchmarks, including morphological classification, molecular prediction, and survival analysis, and outperforms other foundation model baselines overall.
论文发现出处
这些页面提供论文线索，不代表同行评审或质量认证。
观测到的版本
平台记录号代表本站观测到的元数据变化，不是作者修订号。来源日期仅到月份或年份时，按该月或该年首日存档。
记录 #1 · 2026 · 最新观测版本
CARE: A Molecular-Guided Foundation Model with Adaptive Region Modeling for Whole Slide Image Analysis
Foundation models have achieved success in computational pathology, demonstrating generalization across histopathology tasks. However, existing models overlook the heterogeneous and non-uniform organization of regions of interest (ROIs) because they rely on natural image backbones not tailored for tissue morphology. Consequently, they fail to capture the coherent tissue architecture beyond patches, limiting interpretability and clinical relevance. To address these challenges, we present Cross-modal Adaptive Region Encoder (CARE), a foundation model for pathology that partitions WSIs into several morphologically relevant regions. Specifically, CARE employs a two-stage pretraining strategy: (1) a self-supervised unimodal pretraining stage that learns morphological representations from 34,277 whole-slide images (WSIs) without segmentation annotations, and (2) a cross-modal alignment stage that leverages RNA and protein profiles to refine the construction and representation of adaptive regions. This molecular guidance enables CARE to identify biologically relevant patterns and generate irregular yet coherent tissue regions, selecting the representative area as ROI. CARE supports a broad range of pathology-related tasks, using either the ROI feature or the slide-level feature obtained by aggregating adaptive regions. Based on only one-tenth of the pretraining data typically used by mainstream foundation models, CARE achieves superior average performance across 33 downstream benchmarks, including morphological classification, molecular prediction, and survival analysis, and outperforms other foundation model baselines overall.
查看此版本解读 →查看此版本原文 ↗