← 研踪 PaperTrailCVF · CVPR 2026:cvf:c95cc62e8dcfb7ed0d9690453ef81da6 · 记录 #1
EMGauss: Continuous Slice-to-3D Reconstruction via Dynamic Gaussian Modeling in Volume Electron Microscopy
来源日期（仅到年份） 2026
来源记录日期 2026
雷达观测 2026-11-05 03:18
摘要
Volume electron microscopy (vEM) enables nanoscale 3D imaging of biological structures but remains constrained by acquisition trade-offs, leading to anisotropic volumes with limited axial resolution. Existing deep learning methods seek to restore isotropy by leveraging lateral priors; yet their assumptions break down for morphologically anisotropic structures. We present **EMGauss**, a general framework for 3D reconstruction from planar scanned 2D slices with applications in vEM, which circumvents the inherent limitations of isotropy-based approaches. Our key innovation is to reframe slice-to-3D reconstruction as a 3D dynamic scene rendering problem based on Gaussian splatting, where the progression of axial slices is modeled as the temporal evolution of 2D Gaussian point clouds. To enhance fidelity in data-sparse regimes, we incorporate a **Teacher-Student bootstrapping mechanism** that uses high-confidence predictions on unobserved slices as pseudo-supervisory signals. Compared with diffusion- and GAN-based reconstruction methods, EMGauss substantially improves interpolation quality, enables continuous slice synthesis, and eliminates the need for large-scale pretraining. Beyond vEM, it potentially provides a generalizable slice-to-3D solution across diverse imaging domains.
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记录 #1 · 2026 · 最新观测版本
EMGauss: Continuous Slice-to-3D Reconstruction via Dynamic Gaussian Modeling in Volume Electron Microscopy
Volume electron microscopy (vEM) enables nanoscale 3D imaging of biological structures but remains constrained by acquisition trade-offs, leading to anisotropic volumes with limited axial resolution. Existing deep learning methods seek to restore isotropy by leveraging lateral priors; yet their assumptions break down for morphologically anisotropic structures. We present **EMGauss**, a general framework for 3D reconstruction from planar scanned 2D slices with applications in vEM, which circumvents the inherent limitations of isotropy-based approaches. Our key innovation is to reframe slice-to-3D reconstruction as a 3D dynamic scene rendering problem based on Gaussian splatting, where the progression of axial slices is modeled as the temporal evolution of 2D Gaussian point clouds. To enhance fidelity in data-sparse regimes, we incorporate a **Teacher-Student bootstrapping mechanism** that uses high-confidence predictions on unobserved slices as pseudo-supervisory signals. Compared with diffusion- and GAN-based reconstruction methods, EMGauss substantially improves interpolation quality, enables continuous slice synthesis, and eliminates the need for large-scale pretraining. Beyond vEM, it potentially provides a generalizable slice-to-3D solution across diverse imaging domains.
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