← 研踪 PaperTrailCVF · CVPR 2026:cvf:ed7ded9b5e8064602cfa4d8c8dd4d20a · 记录 #1
Diffusion with a Linguistic Compass: Steering the Generation of Clinically Plausible Future sMRI Representations for Early MCI Conversion Prediction
来源日期（仅到年份） 2026
来源记录日期 2026
雷达观测 2026-11-05 02:57
摘要
Early prediction of Mild Cognitive Impairment (MCI) conversion is hampered by a trade-off between immediacy--making fast predictions from a single baseline sMRI--and accuracy--leveraging longitudinal scans to capture disease progression. We propose MCI-Diff, a diffusion-based framework that synthesizes clinically plausible future sMRI representations directly from baseline data, achieving both real-time risk assessment and high predictive performance. First, a multi-task sequence reconstruction strategy trains a shared denoising network on interpolation and extrapolation tasks to handle irregular follow-up sampling and learn robust latent trajectories. Second, an LLM-driven "linguistic compass" is introduced for clinical plausibility sampling: generated feature candidates are quantized, tokenized, and scored by a fine-tuned language model conditioned on expected structural biomarkers, guiding autoregressive generation toward realistic disease patterns. Experiments on ADNI and AIBL cohorts show that MCI-Diff outperforms state-of-the-art baselines, improving early conversion accuracy by 5-12%.
论文发现出处
这些页面提供论文线索，不代表同行评审或质量认证。
观测到的版本
平台记录号代表本站观测到的元数据变化，不是作者修订号。来源日期仅到月份或年份时，按该月或该年首日存档。
记录 #1 · 2026 · 最新观测版本
Diffusion with a Linguistic Compass: Steering the Generation of Clinically Plausible Future sMRI Representations for Early MCI Conversion Prediction
Early prediction of Mild Cognitive Impairment (MCI) conversion is hampered by a trade-off between immediacy--making fast predictions from a single baseline sMRI--and accuracy--leveraging longitudinal scans to capture disease progression. We propose MCI-Diff, a diffusion-based framework that synthesizes clinically plausible future sMRI representations directly from baseline data, achieving both real-time risk assessment and high predictive performance. First, a multi-task sequence reconstruction strategy trains a shared denoising network on interpolation and extrapolation tasks to handle irregular follow-up sampling and learn robust latent trajectories. Second, an LLM-driven "linguistic compass" is introduced for clinical plausibility sampling: generated feature candidates are quantized, tokenized, and scored by a fine-tuned language model conditioned on expected structural biomarkers, guiding autoregressive generation toward realistic disease patterns. Experiments on ADNI and AIBL cohorts show that MCI-Diff outperforms state-of-the-art baselines, improving early conversion accuracy by 5-12%.
查看此版本解读 →查看此版本原文 ↗