← 研踪 PaperTrailCVF · CVPR 2026:cvf:f91da4dc63bdb69d9050d701cc84f2a6 · 记录 #1
Predicting Spatial Transcriptomics from Histology Images via High-Order Multi-Cell Interaction Modeling
来源日期（仅到年份） 2026
来源记录日期 2026
雷达观测 2026-11-05 01:11
摘要
Spatial transcriptomics (ST) links gene expression to tissue architecture and enables predicting spatial expression from H&E-stained whole-slide images (WSIs). However, existing spot- or slide-level predictors focus on single-spot features or pairwise relations, failing to capture high-order, many-to-many cross-cell interactions. As a result, they miss synergistic and antagonistic effects among multiple neighboring cells. Here, we introduce MCToGene, a scalable and accurate framework that explicitly models multi-cell interactions via many-body attention with hierarchical coupling to predict spatial gene expression. MCToGene employs a many-body attention module to encode high-order, many-to-many cross-cell dependencies, enabling context-aware microenvironment modeling. To mitigate the combinatorial burden of many-body modeling, we design a hierarchical interaction module that couples pairwise and many-body representations for feature aggregation and prediction, preserving many-body expressiveness while controlling computation and memory. On HEST-1k and STImage-1K4M, MCToGene surpasses state-of-the-art baselines with 7.85% relative improvement. Ablations confirm that explicit high-order, many-to-many modeling drives these gains, and visualizations demonstrate that multi-cell interactions are essential for biologically coherent spatial predictions.
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记录 #1 · 2026 · 最新观测版本
Predicting Spatial Transcriptomics from Histology Images via High-Order Multi-Cell Interaction Modeling
Spatial transcriptomics (ST) links gene expression to tissue architecture and enables predicting spatial expression from H&E-stained whole-slide images (WSIs). However, existing spot- or slide-level predictors focus on single-spot features or pairwise relations, failing to capture high-order, many-to-many cross-cell interactions. As a result, they miss synergistic and antagonistic effects among multiple neighboring cells. Here, we introduce MCToGene, a scalable and accurate framework that explicitly models multi-cell interactions via many-body attention with hierarchical coupling to predict spatial gene expression. MCToGene employs a many-body attention module to encode high-order, many-to-many cross-cell dependencies, enabling context-aware microenvironment modeling. To mitigate the combinatorial burden of many-body modeling, we design a hierarchical interaction module that couples pairwise and many-body representations for feature aggregation and prediction, preserving many-body expressiveness while controlling computation and memory. On HEST-1k and STImage-1K4M, MCToGene surpasses state-of-the-art baselines with 7.85% relative improvement. Ablations confirm that explicit high-order, many-to-many modeling drives these gains, and visualizations demonstrate that multi-cell interactions are essential for biologically coherent spatial predictions.
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