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新论文 · v1arXiv:2611.11273

Task-adaptive anonymisation enables privacy-preserving sharing of clinical speech data

Ziyun Cui, Haoyu Niu, Wen Wu, Hao Sun, Sihan Zhang, Chang Lei, Yun Zhang, Chunyun Sun 等 15 位作者

原文摘要

Clinical speech is increasingly used for disease screening and clinical assessment, but directly distributing speech recordings poses privacy risks because they contain both speaker-identifying voiceprints and sensitive spoken content. Existing speech anonymisation approaches are primarily developed for general speech applications or task-specific clinical speech and overlook that different clinical tasks rely on distinct speech characteristics, necessitating task-adaptive anonymisation strategies to protect patient privacy while preserving clinical utility. Here we introduce CASA, a clinically adaptive speech anonymisation agent that transforms anonymisation from a fixed processing procedure into a task-guided optimisation process, dynamically tailoring voiceprint and content anonymisation to task-specific privacy and clinical utility requirements. Through recursive self-improvement (RSI), CASA iteratively evaluates and refines anonymisation strategies against task-specific privacy and clinical utility requirements, while learning from these outcomes to guide more efficient planning in subsequent clinical tasks. CASA is validated across 14 clinical tasks encompassing five languages, diverse elicitation paradigms, and mental health, cognitive and voice disorders. CASA preserved disease-related classification performance while meeting speaker-anonymisation requirements across all clinical tasks, versus only 8/14 for the strongest fixed method. Assessments of resistance to speaker re-identification by external attackers and identification and redaction of sensitive personal information in clinical speech further demonstrated CASA's dual protection of speaker identity and sensitive spoken content. Clinical expert assessments further supported the preservation of clinically relevant information and the acceptability of anonymised speech for controlled research sharing.

eess.AS · cs.CL

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.08568

Personalized health coaching via coachable health age and counterfactual wearable trajectories

Simon A. Lee, Zeinab Esmaeilpour, Menglian Zhou, Marius Guerard, Sohrab Sidhu, Alexandru Solot, Hamid Palangi, Pramod Rudrapatna 等 20 位作者

原文摘要

Personalized health coaching requires moving beyond retrospective wearable summaries toward quantitative, actionable behavioral prescriptions. We introduce Coachable Health Age (CHA), an interpretable health-age metric built from modifiable physiological and behavioral signals passively captured by consumer wearables. Across the WEAR-ME (N=2,780), All of Us (N=22,748), and longitudinal Fitbit (N=1,464) cohorts, CHA aligns with established cardiometabolic health constructs and improves prognostic discrimination for incident cardiovascular and metabolic disease beyond age, sex, and body mass index. To enable prospective behavioral optimization, we developed Sensor World Model (SensorWM), an action-conditioned wearable world model pretrained on over 2.2 million person-weeks of longitudinal sensor data from approximately 100,000 participants. SensorWM accurately forecasts multi-week physiological responses to candidate lifestyle changes ($R^2=0.664$), outperforming generic time-series foundation models while preserving downstream clinical signal for diabetes, hypertension, and other health outcomes. Finally, we integrate CHA and SensorWM into an agentic counterfactual coaching system to synthesize personalized 12-week coaching plans. In blinded paired reviews, certified lifestyle coaches preferred counterfactual-grounded plans over plans grounded in wearable history alone for overall quality (71.4%, P < 0.001) and anticipated adherence (71.0%, P < 0.001), and board-certified clinicians judged 99.2% of counterfactual-grounded plans to meet clinical safety criteria (vs. 97.6% of comparison plans). Automated evaluations across the full cohort (N=2,780) also favored counterfactual-grounded plans. By closing the loop between longitudinal tracking, trajectory prediction, and counterfactual coaching, our framework provides a scalable path to systematically improve cardiometabolic health.

q-bio.QM · cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2603.07618

SMAT: Staged Multi-Agent Training for Co-Adaptive Exoskeleton Control

Yifei Yuan, Ghaith Androwis, Xianlian Zhou

原文摘要

Effective exoskeleton assistance requires co-adaptation: as the device alters joint dynamics, the user reorganizes neuromuscular coordination, creating a non-stationary learning problem. Most learning-based approaches do not explicitly account for the sequential nature of human motor adaptation, leading to training instability and poorly timed assistance. We propose Staged Multi-Agent Training (SMAT), a four-stage curriculum inspired by how users acclimate to a wearable device. In SMAT, a musculoskeletal human actor and a bilateral hip exoskeleton actor are trained progressively: the human first learns unassisted gait, then adapts to the added device mass; the exoskeleton subsequently learns a positive assistance pattern against a stabilized human policy, and finally both agents co-adapt with full torque capacity and bidirectional feedback. We implement SMAT in the MyoAssist simulation environment using a 26-muscle lower-limb model and an attached hip exoskeleton. Our musculoskeletal simulations demonstrate that the learned exoskeleton control policy produces an average 10.1% reduction in simulated hip muscle activation relative to the no-assist condition. We validated the learned controller in an offline setting using open-source gait data, then deployed it to a physical hip exoskeleton for treadmill experiments with five subjects. The resulting policy delivers consistent assistance and predominantly positive mechanical power without the need for any explicitly imposed timing shift (mean positive power: 13.6 W at 6 Nm RMS torque to 23.8 W at 9.3 Nm RMS torque, with minimal negative power) consistently across all subjects without subject-specific retraining.

cs.RO · cs.AI · cs.LG

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.37441

Multi-Agent Reinforcement Learning of Co-Adaptive Hip Exoskeleton Control (MARL-Exo) for Metabolic Energy Reduction

Yifei Yuan, Jakob Wolf, Ghaith Androwis, Xianlian Zhou

原文摘要

Objective: This study aims to determine whether a hip-exoskeleton policy trained in simulation, by co-adapting with a musculoskeletal human model under a metabolic-energy reward, reduces the metabolic cost of walking in new users without per-user tuning, and how mechanical-power shaping affects the learned assistance. Methods: We developed MARL-Exo, a multi-agent reinforcement learning framework in which a full-body human model (304 muscle actuators; randomized anatomy, gait, and speed) and a bilateral hip-exoskeleton policy are trained concurrently in two stages. The exoskeleton observes only delayed hip kinematics and its past commands; its reward includes muscle metabolic power from a physiologically based energetics model, alone (Metabolic) or with mechanical-power shaping (Metabolic + Power). The Metabolic policy was deployed and tested without retraining in eight healthy adults walking at 1.25 m/s, using indirect calorimetry. Results: In simulation, the Metabolic policy reduced modeled muscle metabolic power by 13.8% relative to no-device walking, versus 8.8% for Metabolic + Power. On hardware, MARL-Exo reduced net metabolic rate by 18.3 $\pm$ 6.6% relative to Passive in all eight participants. Relative to No-Exo, the mean reduction was 7.4 $\pm$ 10.0%; six participants more than offset the 13.1% device-wearing penalty, walking up to 24.2% below their No-Exo cost. Conclusion: A metabolically informed policy co-adapted in simulation transferred to users without per-user tuning and consistently reduced the metabolic cost of walking with the device, while explicit power shaping reduced the simulated benefit. Significance: Unlike per-user human-in-the-loop optimization, this approach yields a single population-level controller and allows assistance objectives to be screened in simulation before human testing.

cs.RO · cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2608.00715

Staged Multi-Agent Training for Human-Exoskeleton Co-Adaptation: Simulation-Based Learning and Real-World Metabolic and Biomechanical Validation

Yifei Yuan, Jakob Wolf, Ghaith Androwis, Xianlian Zhou

原文摘要

Learning-based controllers can enable exoskeleton assistance to be trained entirely in physics-based simulation, but achieving effective assistance on real users remains challenging because the human and device continuously adapt to one another. We investigate a Staged Multi-Agent Training (SMAT) approach that jointly trains a musculoskeletal human actor and a bilateral hip-exoskeleton actor (control policy) to learn coordinated assistance strategies while accounting for human-device co-adaptation. The resulting policy was transferred to a physical hip exoskeleton and evaluated in eight healthy adults across users and locomotion conditions without subject-specific retraining. Indirect calorimetry was used to compare no-exoskeleton, passive, and active conditions. Active assistance reduced net metabolic rate by 19.7% relative to the passive device (p < 0.001). The policy produced predominantly positive hip mechanical power across subjects, with a positive-power ratio of 0.984, and maintained effective assistance across walking speeds and terrains beyond the training conditions. These results demonstrate that simulation-based multi-agent co-adaptation can produce a single transferable exoskeleton policy that elicits meaningful physiological benefits in real users without subject-specific retraining, providing a framework for reducing the experimental burden of human-in-the-loop controller development.

cs.RO · cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2605.30865Google Research

GlucoFM：面向连续血糖监测的双流基础模型

GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring

Zechen Li, Keerthana Natarajan, Weizhi Zhang, Menglian Zhou, Simon A. Lee, Yuwei Zhang, Maxwell A. Xu, Zeinab Esmaeilpour 等 14 位作者

AI 速读 基于摘要

提出轻量级CGM基础模型GlucoFM，将血糖动态分解为慢变趋势与短期偏差双流，并在大规模无标签CGM数据上预训练，用于代谢表型分类与餐后血糖响应预测。

cs.LG

arXiv ↗PDF ↗
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Continuous glucose monitoring (CGM) provides a dense view of daily metabolic physiology, yet existing generic time-series and CGM-specific foundation models often encode glucose traces as entangled single-stream sequences, leaving their multiscale temporal structure only implicitly modeled. We present GlucoFM, a lightweight CGM foundation model that aligns irregular recordings to a 24-hour chronological grid, preserves observation masks, and decomposes glucose dynamics into slow-varying glycemic trend and short-term deviation streams. GlucoFM is pretrained on 109,066 hours of unlabeled CGM recordings from 477 subjects with masked contextual latent prediction over fused daily representations and temporal dynamics prediction over the two streams. Frozen pre-fusion probes confirm distinct temporal emphasis: state tokens preferentially preserve hourly glucose level, whereas event tokens better retain short-term change. Across four diverse cohorts and seven phenotype-classification tasks, GlucoFM achieves the strongest subject-disjoint linear-probing performance among evaluated baselines, improving average PR-AUC by 4.1 points over the best CGM-specific foundation model, while also supporting strong cross-dataset transfer and few-shot adaptation. Its gains are most pronounced on core metabolic outcomes, leading PR-AUC on all diabetes-risk and $β$-cell dysfunction tasks and on 3 of 4 insulin-resistance tasks. Beyond phenotyping, when combined with recent CGM, meal nutrition, and subject context, the same frozen encoder achieves the lowest two-hour postprandial glycemic response errors among evaluated methods for trajectory, incremental area under the curve, peak rise, and peak timing. Together, these results demonstrate that GlucoFM learns reusable frozen CGM representations spanning metabolic phenotyping and context-conditioned glucose-response prediction.