Yin Fang, Qiao Jin, Shubo Tian, Lauren He, Maya Geer, Noor Naffakh, Ryan Huu-Tuan Nguyen, Zifeng Wang 等 27 位作者
Clinical trials are essential for evidence-based medicine and drug development, but many fail because of insufficient patient enrollment. Although there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world workflows. Here we present TrialGPT 2.0, an AI-assisted clinical trial recommendation system improved for responsible real-world deployment. Rather than asking only whether a patient may qualify, the system assesses which trials warrant further consideration given the patient's current clinical needs and local workflow priorities, and provides structured, inspectable explanations for expert review. Importantly, we evaluated TrialGPT 2.0 retrospectively and prospectively across government research, patient-advocacy, academic medical center, and community-based radiation-oncology settings. In retrospective multicenter cohorts comprising 288 cases, TrialGPT 2.0 retrieved at least one clinician-recommended trial in its top 10 recommendations for approximately 91% of cases while reducing clinician screening time by 55.0%. In a six-month prospective evaluation embedded in an active precision oncology tumor board, TrialGPT 2.0 contributed additional trial opportunities missed by the routine workflow, increasing the number of patient cases with at least one final trial recommendation by 90.9%. To support scientific reproducibility, we also developed NIH-TrialBench, a clinician-authored benchmark comprising 126 diverse synthetic patient vignettes and matching scenarios from 11 NIH Institutes and Centers. Together, these findings support the value of AI to assist clinical trial matching by improving clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.
Recent advances in multimodal retrieval-augmented generation (MM-RAG) have shifted toward minimal parsing, relying on page-level images for producing retriever embeddings and for answer generation. While efficient, this trend often neglects explicit handling of the rich, structured information in complex enterprise documents, instead depending on pre-trained embeddings or vision-language models to implicitly capture such structure. In this work, we take a more direct approach: MM-BizRAG proactively extracts and represents document structure via a document structure-aware split that dynamically routes documents through orientation-specific ingestion pipelines, applying explicit layout-aware parsing for vertically structured documents (e.g., reports) and holistic page-level representations for horizontally structured documents (e.g., slide decks). A unified LLM-driven artifact transformation pipeline with placeholder-based positional alignment preserves natural reading order, while inference-time multimodal assembly decouples retrieval representations from generation context, enabling richer, more grounded answers without any finetuning requirement. Through experiments on a large, heterogeneous enterprise dataset and two public benchmarks (SlideVQA and FinRAGBench-V), MM-BizRAG consistently outperforms state-of-the-art vision-centric baselines by up to 32% points, with especially strong gains on report-style layouts. Furthermore, we introduce FastRAGEval, a single-call LLM Judge metric for fine-grained generative recall that halves RAGChecker’s cost while achieving stronger human alignment.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 6: Industry Track) · 2026 · 正式发表
Mohit Chandra, Siddharth Sriraman Georgia Institute of Technology, Harneet Singh Khanuja Georgia Institute of Technology, Yiqiao Jin, Munmun De Choudhury
Limited access to mental healthcare, extended wait times, and increasing capabilities of Large Language Models (LLMs) has led individuals to turn to LLMs for fulfilling their mental health needs. However, examining the multi-turn mental health conversation capabilities of LLMs remains under-explored. Existing evaluation frameworks typically focus on diagnostic accuracy and win-rates and often overlook alignment with patient-specific goals, values, and personalities required for meaningful conversations. To address this, we introduce MedAgent, a novel framework for synthetically generating realistic, multi-turn mental health sensemaking conversations and use it to create the Mental Health Sensemaking Dialogue (MHSD) dataset, comprising over 2,200 patient–LLM conversations. Additionally, we present MultiSenseEval, a holistic framework to evaluate the multi-turn conversation abilities of LLMs in healthcare settings using human-centric criteria. Our findings reveal that frontier reasoning models yield below-par performance for patient-centric communication and struggle at precise (“hard”) diagnostic capabilities with average accuracy of ~31%. Additionally, we observed variation in model performance based on patient’s persona and performance drop with increasing turns in the conversation. Our work provides a comprehensive synthetic data generation framework, a dataset and evaluation framework for assessing LLMs in multi-turn mental health conversations.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Yiqiao Jin, Kartik Sharma, Vineeth Rakesh VISA, Yingtong Dou VISA, Menghai Pan Visa Research, Mahashweta Das, Srijan Kumar Georgia Institute of Technology
Retrieval-augmented generation (RAG) extends large language models (LLMs) with external knowledge, but it must balance limited effective context, redundant retrieved evidence, and the loss of fine-grained facts under aggressive compression. Pure compression-based approaches reduce input size but often discard fine-grained details essential for factual accuracy. We propose SARA, a hybrid RAG framework that targets answer quality under fixed token budgets by combining natural-language snippets with semantic compression vectors. SARA retains a small set of passages in text form to preserve entities and numerical values, compresses the remaining evidence into interpretable vectors for broader coverage, and uses those vectors for iterative evidence reranking. Across 9 datasets and 5 open-source LLMs spanning 3 model families (Mistral, Llama, and Gemma), SARA consistently improves answer relevance (+17.71), answer correctness (+13.72), and semantic similarity (+15.53), demonstrating the importance of integrating textual and compressed representations for robust, context-efficient RAG.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Yiqiao Jin, Rachneet Kaur J.P. Morgan Chase, Zhen Zeng, Sumitra Ganesh J.P. Morgan Chase, Srijan Kumar Georgia Institute of Technology
Multi-page visual documents such as manuals, brochures, presentations, and posters convey key information through layout, colors, icons, and cross-slide references. While multimodal large language models (MLLMs) offer opportunities in document understanding, current systems struggle with complex, multi-page visual documents, particularly in fine-grained reasoning over elements and pages. We introduce SlideAgent, a versatile agentic framework for understanding multi-modal, multi-page, and multi-layout documents, especially slide decks. SlideAgent employs specialized agents and decomposes reasoning into three specialized levels–global, page, and element–to construct a structured, query-agnostic representation that captures both overarching themes and detailed visual or textual cues. During inference, SlideAgent selectively activates specialized agents for multi-level reasoning and integrates their outputs into coherent, context-aware answers.Extensive experiments show that SlideAgent significantly improves accuracy over both proprietary (+7.9%) and open-source models (+9.8%).
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cs.CL · cs.AI · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Peer review is fundamental to the integrity and advancement of scientific publication. Traditional methods of peer review analyses often rely on exploration and statistics of existing peer review data, which do not adequately address the multivariate nature of the process, account for the latent variables, and are further constrained by privacy concerns due to the sensitive nature of the data. We introduce AgentReview, the first large language model (LLM) based peer review simulation framework, which effectively disentangles the impacts of multiple latent factors and addresses the privacy issue. Our study reveals significant insights, including a notable 37.1% variation in paper decisions due to reviewers' biases, supported by sociological theories such as the social influence theory, altruism fatigue, and authority bias. We believe that this study could offer valuable insights to improve the design of peer review mechanisms. Our code is available at https://github.com/Ahren09/AgentReview.