让下一篇重要论文，不再错过。

User embeddings are central components of modern recommendation, personalization, and behavioral modeling systems. Though these embeddings can compactly encode rich behavioral information, they are inherently dense and opaque, limiting interpretability. To address this gap, we argue that user embeddings can be understood as sparse superpositions of interpretable behavioral modes. This structure is directly predicted by generative models of user behavior for linear embeddings and extends approximately to deep-learning representations by the superposition hypothesis. Superimposed modes can naturally be recovered by sparse dictionary learning methods, such as sparse autoencoders (SAEs), and recovered modes can be automatically named and queried in natural language. We validate mode recovery against known ground truth on synthetic data, where SAEs recover modes better than classical sparse baselines, including on transformer-encoded embeddings. We then apply the method to classical and transformer-based user embeddings from two real-world datasets. We also show how the corresponding natural-language labels enable zero-shot audience retrieval and characterization over embeddings never trained on text. The framework is post-hoc and model-agnostic, requiring no modification to the upstream embedding system.

Large language models (LLMs) are increasingly used in biomedical and cognitive neuroscience, but their ability to reason reliably over heterogeneous knowledge graphs (KGs) remains unclear. We benchmark five LLMs (GPT-5.1, Gemini 2.0 Pro, Llama 3, Qwen, and BioGPT) across five KGs: DrugBank, NeuroSynth, Cognitive Atlas, Brain Map, and GDPKG. We introduce a multitier query dataset to evaluate reasoning depth and factual accuracy under KG-aware (graph-grounded) and KG-agnostic conditions. Inter-annotator agreement was substantial, with Cohen's kappa of 0.781 (range: 0.753-0.807) and Fleiss' kappa of 0.77. Results show that general-purpose models, particularly GPT-5.1 and Gemini 2.0 Pro, generally outperform domain-specific models on multi-hop and high-level reasoning tasks, although performance declines as query complexity increases. KG grounding reduces hallucination rates across all evaluated models. Contrary to our initial hypothesis, domain-specific models do not consistently outperform general-purpose models on specialized tasks without graph grounding. These findings highlight the value of combining broad language-model capabilities with structured domain knowledge. We provide practical guidance for selecting LLM-KG integration strategies based on task complexity and computational constraints, and discuss hybrid neurosymbolic architectures for personalized medicine, cognitive disorder diagnosis, and explainable AI.

Robot-mediated rehabilitation has the potential to deliver high-intensity, individualized therapy, but existing systems (which have not consistently improved outcomes) typically prescribe kinematic trajectories rather than explicitly targeting the neuromotor activations thought to support recovery. To address this gap, and ultimately enable activation-optimizing rehabilitation robot behavior, we present a personalizable transformer-based model mapping individuals' muscle activations (as measured via surface electromyography) to prescribed contact force trajectories when interacting with an end-effector rehabilitation robot. The model uses a transformer encoder-decoder leveraging rotary positional embeddings (RoPE) to generate a latent representation of trajectory-relevant and user-specific neuromotor factors, and augments trajectory prediction with flow matching to produce a distribution over plausible prescriptions biased toward the training distribution. Using data from 16 healthy participants completing 15 isometric trajectory tracking tasks, we evaluate generalization across held-out tasks and users, as well as the feasibility of user-specific fine-tuning within a therapy-session timescale. The model achieves mean trajectory prediction errors of <8% on held out tasks and users, with effectively instantaneous deterministic inference and sub-second sampling of trajectory distributions. An initial test using the model during live rehabilitation tasks demonstrates that, on average, participants reach the target neuromotor activations with just 15% error accumulated throughout the task. These results provide a proof of concept for data-driven, activation-targeted trajectory prescription in robot-mediated rehabilitation and establish a foundation for future validation in clinical populations. Data and code have been open-sourced as part of the OpenRobotRehab project on SimTK.