Isotropic microscopy reconstruction remains challenging because the anisotropic point spread function in optical systems yields much poorer axial resolution and hampers accurate 3D analysis. Hardware strategies can approach isotropy, yet they are complex, costly, susceptible to sidelobes, and introduce phototoxicity. Deep learning approaches reduce acquisition burden, yet synthetic pipelines often rely on Gaussian blur mismatched to physical degradation, and many methods lack explicit volumetric geometry constraints as they process 2D slices independently, resulting in low-fidelity reconstructions. To address these challenges, we present MicroFM, which synthesizes realistic training data using physical PSFs matched to the target microscope. MicroFM also introduces a physics-guided flow-matching framework for isotropic microscopy reconstruction, guided by a continuous implicit geometry prior to achieve high-fidelity isotropic recovery. Across four fluorescence microscopy systems and datasets, MicroFM achieves state-of-the-art (SOTA) performance, producing sharper structures, more isotropic spectra, and substantial gains in both full-reference and no-reference metrics.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表
High dynamic range novel view synthesis (HDR-NVS) reconstructs scenes with dynamic details by fusing multi-exposure low dynamic range (LDR) views, yet it struggles to capture ambient illumination-dependent appearance. Implicitly supervising HDR content by constraining tone-mapped results fails in correcting abnormal HDR values, and results in limited gradients for Gaussians in under/over-exposed regions. To this end, we introduce PhysHDR-GS, a physically inspired HDR-NVS framework that models scene appearance via intrinsic reflectance and adjustable ambient illumination. PhysHDR-GS employs a complementary image-exposure (IE) branch and Gaussian-illumination (GI) branch to faithfully reproduce standard camera observations and capture illumination-dependent appearance changes, respectively. During training, the proposed cross-branch HDR consistency loss provides explicit supervision for HDR content, while an illumination-guided gradient scaling strategy mitigates exposure-biased gradient starvation and reduces under-densified representations. Experimental results across realistic and synthetic datasets demonstrate our superiority in reconstructing HDR details (e.g., a PSNR gain of 2.04 dB over HDR-GS), while maintaining real-time rendering speed (up to 76 FPS). Code and models are available at https://huimin-zeng.github.io/PhysHDR-GS/.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表