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首次观测 · 记录 #1CVF · CVPR 2026:cvf:227ffd69cb01077e59fc589597c00362CVF · CVPR 2026

Fuel Gauge: Estimating Chain-of-Thought Length Ahead of Time in Large Multimodal Models

Yang, Yuedong, Wei, Xiwen, Munir, Mustafa, Marculescu, Radu

原文摘要

Reasoning Large Multi-modality Models (LMMs) have become the de facto choice for many applications. However, these models rely on a Chain-of-Thought (CoT) process that is lengthy and unpredictable at runtime, often resulting in inefficient use of computational resources (due to memory fragmentation) and sub-optimal accuracy (due to under- and over-thinking). Empirical evidence shows a strong correlation between CoT length and task difficulty. This suggests that the CoT length can be estimated ahead of time based on a hidden parameter representing the amount of "fuel" available to support the reasoning process. Based on this insight, we propose Fuel Gauge, the first method which extracts this hidden signal and predicts CoT length ahead of time. We demonstrate the utility on the Fuel Gauge on two downstream tasks: predictive KV cache allocation, which addresses memory fragmentation in LMM serving systems, and CoT length modulation, which mitigates under-thinking and over-thinking. Extensive experiments on LMMs across text-only, image-text, and video-text question answering benchmarks demonstrate the effectiveness, generalizability, and practical value of Fuel Gauge. For example, on the GPQA-Diamond benchmark, our Fuel Gauge achieves less than half the CoT length prediction error compared to the baseline; this translates into a 13.37x reduction in the memory allocation frequency.

cs.CV

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

首次观测 · 记录 #1CVF · CVPR 2026:cvf:810ef0b1c50338f55a40a2997f516a8fCVF · CVPR 2026

Deciphering Genotype-Phenotype Mechanisms from High-Content Profiling via Knowledge-Guided Multi-modal Graph Learning

Lin, Hanjing, Rao, Jiahua, Sun, Youhan, Xie, Jiancong, Yang, Yuedong

原文摘要

Understanding genotype-phenotype relationships is pivotal for advancing biomedical research, drug discovery, and precision medicine. With the rise of high-throughput cellular imaging, it is essential to tightly integrate high-content cellular morphology with structured biological knowledge to extract cellular-scale evidence for genotype-to-phenotype mapping.However, integrating high-dimensional, heterogeneous, and noisy phenotypes with structured knowledge remains challenging. Prior approaches typically treat phenotypes as node features, overlooking that phenotypes primarily convey cellular-scale relational signals about how perturbations reshape interactions. We present KERNEL, a knowledge-guided multimodal graph learning framework that integrates cellular imaging phenotypes into a unified knowledge graph to predict genotype-phenotype interactions, including GRN inference, drug-target interaction prediction, and subtype-specific subnetwork discovery. KERNEL dynamically augments task-relevant edges from noisy phenotypic signals, explicitly learns per-edge confidence and marginal utility, and uses knowledge gating to align graph topology with mechanistic pathways. Across large-scale imaging and single-cell datasets, KERNEL consistently outperforms state-of-the-art baselines, e.g., up to 38.1% AUPR improvement for GRN inference, while delivering more accurate and interpretable DTI and subtype subnetwork discovery, demonstrating robust mechanism learning from richer, harder-to-denoise phenotypes.

cs.CV

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

首次观测 · 记录 #1CVF · CVPR 2026:cvf:f91da4dc63bdb69d9050d701cc84f2a6CVF · CVPR 2026

Predicting Spatial Transcriptomics from Histology Images via High-Order Multi-Cell Interaction Modeling

Sun, Youhan, Rao, Jiahua, Du, Kangrui, Xie, Jiancong, Yang, Yuedong

原文摘要

Spatial transcriptomics (ST) links gene expression to tissue architecture and enables predicting spatial expression from H&E-stained whole-slide images (WSIs). However, existing spot- or slide-level predictors focus on single-spot features or pairwise relations, failing to capture high-order, many-to-many cross-cell interactions. As a result, they miss synergistic and antagonistic effects among multiple neighboring cells. Here, we introduce MCToGene, a scalable and accurate framework that explicitly models multi-cell interactions via many-body attention with hierarchical coupling to predict spatial gene expression. MCToGene employs a many-body attention module to encode high-order, many-to-many cross-cell dependencies, enabling context-aware microenvironment modeling. To mitigate the combinatorial burden of many-body modeling, we design a hierarchical interaction module that couples pairwise and many-body representations for feature aggregation and prediction, preserving many-body expressiveness while controlling computation and memory. On HEST-1k and STImage-1K4M, MCToGene surpasses state-of-the-art baselines with 7.85% relative improvement. Ablations confirm that explicit high-order, many-to-many modeling drives these gains, and visualizations demonstrate that multi-cell interactions are essential for biologically coherent spatial predictions.

cs.CV

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表