Hybrid HE/2PC private neural network inference remains bottlenecked by prime-modulus homomorphic arithmetic in convolution and by a precision flow that runs ReLU at doubled bitwidth before invoking a separate truncation protocol. We present Jaguar, a system built on a single design choice--a power-of-two ciphertext ring--that addresses both. The choice enables SPA-Conv, a coefficient-domain convolution kernel that replaces NTT-centric polynomial multiplication with Scalar-Polynomial Accumulation, and an exact ciphertext-side truncation by local right shifts that lets ReLU run directly at the target fixed-point precision and eliminates the post-ReLU truncation protocol. Where NTT remains genuinely useful--at the client, for the single polynomial multiplication during decryption--we recover it through an auxiliary NTT prime, preserving the power-of-two protocol substrate while keeping decryption O(N log N). On ImageNet-scale ResNet-18, ResNet-50, and MobileNetV2 with AVX disabled, Jaguar achieves 2.07-3.72x lower end-to-end latency than Cheetah and 2.16-3.36x lower than Rhombus, with 1.16-1.76x lower communication than Cheetah.
Wearable devices generate continuous physiological and behavioral data, but converting these signals into clinically reviewable biomarker hypotheses remains labor-intensive. We introduce CoDaS, an AI co-data-scientist that integrates multi-agent hypothesis generation, deterministic statistical analysis, adversarial validation and literature-grounded interpretation under human oversight. Across three wearable cohorts comprising 9,279 participant-observations, CoDaS prioritized candidate associations for mental-health and metabolic endpoints after internal checks for replication, stability, robustness and leakage. The system identified related circadian-instability signals associated with depression, including sleep-duration variability in DWB ($ρ$ = 0.252, $p$ < 0.001) and sleep-onset variability in GLOBEM ($ρ$ = 0.126, $p$ < 0.001), and derived a wearable cardiovascular-fitness index associated with insulin resistance (steps/resting heart rate; $ρ$ = -0.374, $p$ < 0.001). Adding these features to demographic models produced modest gains ($ΔR^2$ = 0.040 for depression, 0.021 for insulin resistance). In a 12-clinician review totaling approximately 25 active hours, clinician validity judgments aligned with CoDaS confidence tiers ($ρ$ = 0.67, $p$ = 0.005), whereas added clinical value and confidence to act were rated lower. CoDaS supports traceable, hypothesis-generating prioritization of wearable candidate biomarkers.