Language-aligned and self-supervised visual encoders offer complementary strengths in semantic abstraction and spatial detail. Harnessing this complementarity requires enriching local features while retaining distinctions between semantically related patches. We introduce PAIQ, a patch-aligned semantic injection framework that combines content-based cross-encoder matching with orthogonally constrained residual updates. Using DINOv3 patch features as the spatial base, PAIQ aggregates complementary SigLIP features through joint source allocation and injects the aggregate--base differences through a shared orthogonal transformation Q. This rotation adapts update directions while preserving residual norms and pairwise angles. For fixed projected features, we derive conditions for patch separability under similar semantic aggregates and show that rotation adds a nonnegative separation term over direct interpolation when the aggregate is shared. Only the projection and fusion parameters are trained; both visual encoders and the language model remain frozen, and fusion retains 196 visual tokens. Across diverse language backbones, PAIQ yields broad gains in judge-assessed correctness and reductions in hallucination severity over single-encoder interfaces on image description and visual question answering. On the 2B and 9B Qwen backbones, this compact interface outperforms the strongest evaluated fusion or token-compression baselines by about 2.9 correctness points on average.
GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring
Zechen Li, Keerthana Natarajan, Weizhi Zhang, Menglian Zhou, Simon A. Lee, Yuwei Zhang, Maxwell A. Xu, Zeinab Esmaeilpour 等 14 位作者
AI 速览：提出轻量级CGM基础模型GlucoFM，将血糖动态分解为慢变趋势与短期偏差双流，并在大规模无标签CGM数据上预训练，用于代谢表型分类与餐后血糖响应预测。
Continuous glucose monitoring (CGM) provides a dense view of daily metabolic physiology, yet existing generic time-series and CGM-specific foundation models often encode glucose traces as entangled single-stream sequences, leaving their multiscale temporal structure only implicitly modeled. We present GlucoFM, a lightweight CGM foundation model that aligns irregular recordings to a 24-hour chronological grid, preserves observation masks, and decomposes glucose dynamics into slow-varying glycemic trend and short-term deviation streams. GlucoFM is pretrained on 109,066 hours of unlabeled CGM recordings from 477 subjects with masked contextual latent prediction over fused daily representations and temporal dynamics prediction over the two streams. Frozen pre-fusion probes confirm distinct temporal emphasis: state tokens preferentially preserve hourly glucose level, whereas event tokens better retain short-term change. Across four diverse cohorts and seven phenotype-classification tasks, GlucoFM achieves the strongest subject-disjoint linear-probing performance among evaluated baselines, improving average PR-AUC by 4.1 points over the best CGM-specific foundation model, while also supporting strong cross-dataset transfer and few-shot adaptation. Its gains are most pronounced on core metabolic outcomes, leading PR-AUC on all diabetes-risk and $β$-cell dysfunction tasks and on 3 of 4 insulin-resistance tasks. Beyond phenotyping, when combined with recent CGM, meal nutrition, and subject context, the same frozen encoder achieves the lowest two-hour postprandial glycemic response errors among evaluated methods for trajectory, incremental area under the curve, peak rise, and peak timing. Together, these results demonstrate that GlucoFM learns reusable frozen CGM representations spanning metabolic phenotyping and context-conditioned glucose-response prediction.
Girish Narayanswamy, Maxwell A. Xu, A. Ali Heydari, Samy Abdel-Ghaffar, Marius Guerard, Kara Vaillancourt, Zhihan Zhang, Jake Garrison 等 40 位作者
While ubiquitous wearable sensors capture a wealth of behavioral and physiological information, effectively transforming these signals into personalized health insights is challenging. Specifically, converting low-level sensor data into representations capable of characterizing higher-level states is difficult due to high phenotypic diversity and variation in individual baseline health, physiology, and lifestyle factors. Moreover, collecting wearable data paired with health outcome annotations is laborious and expensive, and retrospective annotation remains practically unfeasible, contributing to a scarcity of data with high-quality labels. To overcome these limitations, we propose a foundation model for wearable health that is pretrained on more than one trillion minutes of unlabeled sensor signals drawn from a large cohort of five million participants. We demonstrate that the joint scaling of model capacity and pretraining data volume leads to systematic improvements in performance, as evaluated on a diverse set of 35 health prediction tasks, spanning cardiovascular, metabolic, sleep, and mental health, as well as lifestyle choices and demographic factors. We find that this population scale representation unlocks label-efficient few-shot learning and generative capabilities for robust daily metric estimation. To further leverage this learned representation, we deploy a classroom of LLM agents to autonomously search the space of downstream predictive heads built on the model embeddings, showing broad performance improvements that increase with LLM model capacity. Finally, we show how integrating these downstream predictors into a Personal Health Agent can support model responses that are more relevant, contextually aware, and safe, and we validate this via 1,860 ratings from a cohort of clinicians.
Yuwei Zhang, Wenhao Yu OpenAI, Shangbin Feng University of Washington, Yifan Zhu, Letian Peng, Jayanth Srinivasa Cisco, Gaowen Liu, Jingbo Shang University of California, San Diego
Despite significant advances in large language models (LLMs), their knowledge memorization capabilities remain underexplored, due to the lack of standardized and high-quality testing grounds. In this paper, we introduce a novel, real-world and large-scale knowledge injection benchmark that continuously evolves without human intervention. Specifically, we propose WikiDYK, which leverages recently-added and expert-curated facts from Wikipedia’s “Did You Know...” entries. Each entry is converted into multiple question–answer pairs spanning diverse task formats from easy cloze prompts to complex multi-hop questions. WikiDYK currently contains 12,290 facts and 77,180 questions, and its design allows for seamless extension with future updates from Wikipedia editors. Through extensive experiments using continued pre-training, we reveal a surprising insight: despite their prevalence in modern LLMs, Causal Language Models (CLMs) demonstrate significantly weaker knowledge memorization capabilities compared to Bidirectional Language Models (BiLMs), exhibiting a 23% lower accuracy in terms of reliability. To compensate for the smaller scales of current BiLMs, we introduce a modular collaborative framework utilizing ensembles of BiLMs as external knowledge repositories to integrate with LLMs. Experiment shows that this framework further improves the reliability accuracy by up to 29.1%. Code: https://github.com/zhang-yu-wei/WikiDYK.
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Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表