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新论文 · v1arXiv:2611.13233

Decisions by Discrimination: Differential Evidence for Medical Reasoning

Yunpeng Xiao, Yuzhang Xie, Junhao Huang, Carl Yang, Xiao Hu, Kai Shu

原文摘要

Large language models (LLMs) are increasingly studied for clinical decision support, and medical question answering provides a testbed for evaluating this capability. In particular, medical multiple-choice questions (MCQs) reflect a core challenge in clinical decision-making: plausible options often share overlapping evidence, while only a few decisive factors distinguish the correct option from incorrect ones. However, existing retrieval-based and reasoning-oriented methods mainly focus on supplying broadly relevant knowledge or eliciting reasoning paths, rather than identifying the compact differential evidence that separates confusing alternatives. In this work, we present a retrieval-grounded differential evidence framework for medical MCQs. Our method extracts option-specific pieces of differential evidence and organizes them into concise evidence prompts for answer selection. This design better aligns external knowledge with differential reasoning while reducing irrelevant context. Experiments show consistent accuracy gains across multiple datasets and target LLMs. Ablation studies further show that our framework outperforms both directly using retrieved evidence chunks and closed-source LLM-generated general hints, and that its improvements are not solely explained by answer-proximal guidance, but are consistent with differential evidence serving as a compact aid for reasoning over competing alternatives. Our findings also offer insights for medical reasoning and other decision-making settings with multiple possible choices.

cs.AI

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2511.09895

SE-Diff: Simulator and Experience Enhanced Diffusion Model for Comprehensive ECG Generation

Xiaoda Wang, Kaiqiao Han, Yuhao Xu, Xiao Luo, Yizhou Sun, Wei Wang, Carl Yang

原文摘要

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Electrocardiograms (ECGs) are the most widely used non-invasive tool for cardiac assessment, yet large, well-annotated ECG corpora are scarce due to cost, privacy, and workflow constraints. Generating ECGs can be beneficial for the mechanistic understanding of cardiac electrical activity, enable the construction of large, heterogeneous, and unbiased datasets, and facilitate privacy-preserving data sharing. Generating realistic ECG signals from clinical context is important yet underexplored. Recent work has leveraged diffusion models for text-to-ECG generation, but two challenges remain: (i) existing methods often overlook the physiological simulator knowledge of cardiac activity; and (ii) they ignore broader, experience-based clinical knowledge grounded in real-world practice. To address these gaps, we propose SE-Diff, a novel physiological simulator and experience enhanced diffusion model for comprehensive ECG generation. SE-Diff integrates a lightweight ordinary differential equation (ODE)-based ECG simulator into the diffusion process via a beat decoder and simulator-consistent constraints, injecting mechanistic priors that promote physiologically plausible waveforms. In parallel, we design an LLM-powered experience retrieval-augmented strategy to inject clinical knowledge, providing more guidance for ECG generation. Extensive experiments on real-world ECG datasets demonstrate that SE-Diff improves both signal fidelity and text-ECG semantic alignment over baselines, proving its superiority for text-to-ECG generation. We further show that the simulator-based and experience-based knowledge also benefit downstream ECG classification.

cs.LG · cs.AI

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2605.12541

PPG2ECG: Physiology-Guided Latent Rectified Flow for Electro-Hemodynamic PPG-to-ECG Generation

Xiaoda Wang, Minxiao Wang, Kaiqiao Han, Defu Cao, Ching Chang, Yidan Shi, Runze Yan, Xiao Luo 等 13 位作者

原文摘要

Electrocardiography (ECG) is the clinical standard for cardiac assessment but requires dedicated hardware that does not scale to daily-life monitoring. Photoplethysmography (PPG) is ubiquitous in wearables but lacks ECG-specific diagnostic morphology and is corrupted by motion and sensor noise. PPG-to-ECG generation aims to bridge this gap by recovering electrical morphology and timing from peripheral pulse signals. However, existing methods largely rely on statistical alignment and data-driven generation. They fail to explicitly structure the latent space around physiology-aware electro-hemodynamic factors and lack constraints from forward physiological dynamics. To address these challenges, we propose PPG2ECG, a physiology-guided latent rectified flow framework. PPG2ECG introduces an electro-hemodynamic simulator that co-models ECG and PPG through shared cardiac phase dynamics. Guided by this simulator, a Physiology-Aware AutoEncoder learns a structured electro-hemodynamic latent space. Then we integrate this simulator guidance into a PPG-conditioned latent rectified flow, enforcing ECG-side morphology consistency and ECG-to-PPG forward hemodynamic consistency during generative transport. Experiments on the large-scale MC-MED dataset demonstrate that PPG2ECG significantly improves PPG-to-ECG generation and downstream cardiovascular disease classification, proving its ability to generate ECGs that are both signal-faithful and physiologically plausible under the ECG-to-PPG hemodynamic pathway

eess.SP · cs.AI · cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2510.14254

Benchmarking Generalist and Specialist Time-Series Foundation Models for PPG-Based Health Assessment

Saurabh Kataria, Yi Wu, Zhaoliang Chen, Hyunjung Gloria Kwak, Yuhao Xu, Lovely Yeswanth Panchumarthi, Ran Xiao, Jiaying Lu 等 26 位作者

原文摘要

Time-series Foundation Models (FMs) are pretrained on either heterogeneous corpora or specific signal domains. Using Photoplethysmography (PPG) as a representative modality, we compare generalist time-series FMs, PPG-specialist FMs, and traditional machine learning (ML) baselines for PPG-based health assessment. We conduct a two-stage benchmark. First, we evaluate multiple FM families across 23 downstream evaluations (e.g., atrial fibrillation detection, vital-sign estimation). Second, we conduct a focused four-FM comparison (MOMENT, Chronos-2, GPT-PPG, MOMENT-PPG) at multiple model sizes on an expanded 51-task suite, under both frozen-backbone and full-model tuning, to study tuning strategy, model scaling, and cross-dataset transfer. The multi-model benchmark shows that PPG-specialist FMs achieve the strongest aggregate performance, but their advantage is not uniform: generalist FMs remain competitive on several tasks, and traditional ML baselines outperform FMs on selected clinical regression tasks. The focused analysis shows that the advantage of PPG-specific pretraining appears mainly with frozen backbones and on targets that the waveform directly reflects, such as atrial fibrillation and vital signs. Full-model tuning narrows this advantage, model rankings change with the tuning strategy, and the largest model variant is the best choice in only about one-third of cases. Additionally, controlled experiments with two generalist models show that initializing PPG pretraining from generalist checkpoints provides an early advantage over training from scratch, even when the pretrained features offer little downstream benefit. Together, these findings suggest that PPG-specific pretraining is useful but task-dependent, and that FMs should be evaluated against simpler statistical, traditional ML, and clinical history-based baselines.

cs.LG

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arXiv ↗PDF ↗
版本更新 · v4arXiv:2406.16715

GC4NC: A Benchmark Framework for Graph Condensation on Node Classification with New Insights

Shengbo Gong, Juntong Ni, Noveen Sachdeva, Carl Yang, Wei Jin

原文摘要

Graph condensation (GC) is an emerging technique designed to learn a significantly smaller graph that retains the essential information of the original graph. This condensed graph has shown promise in accelerating graph neural networks while preserving performance comparable to those achieved with the original, larger graphs. Additionally, this technique facilitates downstream applications like neural architecture search and deepens our understanding of redundancies in large graphs. Despite the rapid development of GC methods, particularly for node classification, a unified evaluation framework is still lacking to systematically compare different GC methods or clarify key design choices for improving their effectiveness. To bridge these gaps, we introduce \textbf{GC4NC}, a comprehensive framework for evaluating diverse GC methods on node classification across multiple dimensions including performance, efficiency, privacy preservation, denoising ability, NAS effectiveness, and transferability. Our systematic evaluation offers novel insights into how condensed graphs behave and the critical design choices that drive their success. These findings pave the way for future advancements in GC methods, enhancing both performance and expanding their real-world applications. Our code is available at https://github.com/Emory-Melody/GraphSlim/tree/main/benchmark.

cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2605.09806

LEAD: Length-Efficient Adaptive and Dynamic Reasoning for Large Language Models

Songtao Wei, Yi Li, Zhikai Li, Xu Hu, Yuede Ji, Guanpeng Li, Feng Chen, Carl Yang 等 10 位作者

原文摘要

Large reasoning models, such as OpenAI o1 and DeepSeek-R1, tend to become increasingly verbose as their reasoning capabilities improve. These inflated Chain-of-Thought (CoT) trajectories often exceed what the underlying problems require, wasting compute, latency, and context budgets. While introducing length-based efficiency rewards during reinforcement learning offers a natural remedy, existing methods struggle with two fundamental challenges: the optimal balance between correctness and efficiency is non-stationary throughout training, and intrinsic reasoning budgets vary drastically across problems. Relying on static reward weights and global length constraints inevitably forces a compromise between degraded accuracy and unrealized compression. To overcome these limitations, we propose LEAD (Length-Efficient Adaptive and Dynamic reasoning), a method that replaces static heuristics with online, self-adaptive mechanisms. LEAD dynamically calibrates the correctness--efficiency trade-off at each step using a Potential-Scaled Instability, directing optimization capacity to the most informative learning signal. Furthermore, it estimates an adaptive per-problem target length online based on the model's own correct rollouts, applying a symmetric efficiency reward that penalizes both overthinking and over-compression. Evaluated on five mathematical reasoning benchmarks, LEAD achieves the highest accuracy and Accuracy-Efficiency Score among RL-trained efficient-reasoning methods in our matched comparisons while producing substantially shorter outputs than the base model.

cs.LG · cs.AI

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arXiv ↗PDF ↗
版本更新 · v4arXiv:2605.16679

CHI-Bench: Can AI Agents Automate End-to-End, Long-Horizon, Policy-Rich Healthcare Workflows?

Haolin Chen, Deon Metelski, Leon Qi, Tao Xia, Joonyul Lee, Steve Brown, Kevin Riley, Frank Wang 等 33 位作者

原文摘要

End-to-end automation of realistic healthcare operations stresses three capabilities underrepresented in current benchmarks: policy density, decisions must be grounded in a large library of medical, insurance, and operational rules; Multi-role composition: a single task requires the agent to play multiple roles with handoffs; and multilateral interaction: intermediate workflow steps are multi-turn dialogs, such as peer-to-peer review and patient outreach. We introduce $χ$-Bench, a benchmark of long-horizon healthcare workflows across three domains: provider prior authorization, payer utilization management, and care management. Each task hands the agent a clinical case in a high-fidelity simulator of 20 healthcare apps exposed via 87 MCP tools, which it must drive to a terminal status through tool calls and writing the role's artifacts, guided by a 1,290+ document managed-care operations handbook skill. Across 30 agent harness/models configurations, the best agent resolves only 28.0% of tasks, no agent clears 20% on strict pass^3, and executing all tasks in a single session slumps the performance to 3.8%. These results raise the hypothesis that similar gaps are likely to surface in other policy-dense, role-composed, irreversible enterprise domains.

cs.CL · cs.AI

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arXiv ↗PDF ↗
首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.791ACL Anthology · ACL 2026

OpenRubrics: Towards Scalable Synthetic Rubric Generation for Reward Modeling and LLM Alignment

Tianci Liu, Ran Xu Google DeepMind, Tony Yu DeepLab, Ilgee Hong Georgia Institute of Technology, Carl Yang Emory University, Tuo Zhao, Haoyu Wang State University of New York at Albany

原文摘要

Reward modeling lies at the core of reinforcement learning from human feedback (RLHF), yet most existing reward models rely on scalar or pairwise judgments that fail to capture the multifaceted nature of human preferences. Recent studies have explored rubrics-as-rewards (RaR) that uses structured criteria to capture multiple dimensions of response quality. However, producing rubrics that are both reliable and scalable remains a key challenge. In this work, we introduce OpenRubrics, a diverse, large-scale collection of (prompt, rubric) pairs for training rubric-generation and rubric-based reward models. To elicit discriminative and comprehensive evaluation signals, we introduce Contrastive Rubric Generation (CRG), which derives both hard rules (explicit constraints) and principles (implicit qualities) by contrasting preferred and rejected responses. We further remove noisy rubrics via preserving preference–label consistency. Across multiple reward-modeling benchmarks, our rubric-based reward model, Rubric-RM, surpasses strong size-matched baselines by 8.4%. These gains transfer to policy models on instruction-following and biomedical benchmarks.The model weights and datasets are publicly available at https://huggingface.co/OpenRubrics.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表