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新论文 · v1arXiv:2611.17104

TuMAP：一种双视角、形态型感知的病理组学流程，用于量化肾小管重塑

TuMAP: A Dual-View, Morphotype-Aware Pathomics Pipeline for Quantifying Renal Tubular Remodeling

Ruijie Wu, Yuechen Yang, Yanfan Zhu, Yu Wang, Shilin Zhao, Ming-Tsun Tsai, Szu-Yuan Li, Shuo-Ming Ou 等 11 位作者

AI 速读 基于摘要

作者提出 TuMAP 流程，结合双视角基础模型表征、形态型标注与患者级统计推断，从 PAS 染色肾活检切片中量化肾小管形态型组成及形态型内差异。

cs.CV · eess.IV

arXiv ↗PDF ↗
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Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.

版本更新 · v4arXiv:2603.09722

A Novel Two-Parameter Penalty: Relaxation Degree Analysis and Sparse Signal Recovery

Ziwei Li, Wengu Chen, Huanmin Ge, Dachun Yang

原文摘要

In this article, we introduce a nonconvex two-parameter penalty function $P_{a,p}$, parameterized by $a\in(0,\infty)$ and $p\in(0,1]$, and the relaxation degree RD$_P$ for a separable nonconvex penalty function $P$. Based on $P_{a,p}$, we further propose the $P_{a,p}$ minimization framework for sparse signal recovery. This framework generalizes the TL1 minimization model established by S. Zhang and J. Xin (corresponding to the special case $p=1$) and provides a unified family of nonconvex penalty functions for sparse signal recovery. Using the sparse convex-combination technique, we establish both exact and stable sparse signal recovery under the restricted isometry property (RIP). To efficiently solve the resulting nonconvex optimization problem, we apply a modified iteratively re-weighted least squares method and the difference of convex functions algorithm (DCA) to develop the IRLSTLp algorithm for unconstrained $P_{a,p}$ minimization and prove some convergence results. Finally, numerical experiments compare recovery and runtime against single- and double-loop baselines, examine sensitivity to $(a,p)$, and assess the empirical correlation between RD$_{P_{a,p}}$ and recovery within the proposed family.

math.FA · cs.IT · math.CA

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.05925

3D Banff Glomerulitis Scoring for Kidney Transplant Pathology: Feasibility Study for Volumetric Quantification

Yanfan Zhu, Junchao Zhu, Ruining Deng, Shilin Zhao, Yu Wang, Yaohong Wang, Yuechen Yang, Chongyu Qu 等 15 位作者

原文摘要

Quantifying glomerular inflammation in kidney-transplant biopsies is traditionally performed on single whole-slide sections using the Banff "most-severe section" rule, despite the inherently three-dimensional nature of lesion distribution. This 2D based assessment might lead to instability when inflammation varies across slices. This paper reports a feasibility study examining the technical feasibility and clinical relevance of extending Banff scoring into three dimensions. To this end, we propose a 3D Banff lesion-scoring framework that aligns serial sections, reconstructs glomerular identities across depth, and integrates inflammatory-cell counts in 3D under three scoring strategies: Compatible, Volumetric, and Deduplicated Volumetric. In the experiments, glomerulitis (g-scores) was used as an example Banff metric and applied to multi-section renal allograft biopsies. Our findings indicate that 3D Banff g-scores are more consistent across sections and, under the semi-automatic setting, the Volumetric strategy correlates more strongly with clinical biomarkers than traditional 2D scores. These results show that 3D volumetric quantification offers promising added value, underscoring the potential benefit of 3D-aware Banff scoring for kidney transplant pathology.

cs.CV

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arXiv ↗PDF ↗
版本更新 · v3arXiv:2610.32660

WiMoT: Replay-Free Continual Wi-Fi Sensing via Moment Transport

Chunchun Yang, Yang Cao, Zhitang Chen

原文摘要

Continual Wi-Fi sensing must learn new rooms or users (plasticity) while keeping earlier ones (stability), yet sensing nodes often cannot retain channel state information (CSI) for privacy and storage reasons. We propose WiMoT (Wi-Fi Moment Transport), which stores the per-class feature mean and covariance of every earlier domain instead of samples. Stored statistics become stale when the representation changes, so WiMoT restricts the change to an affine map on a frozen feature basis and applies the same map to the statistics, which then stay valid without old samples. Supervised contrastive learning learns the new domain, a closed-form loss on the stored statistics keeps earlier classes separable, and a Gaussian discriminant classifier refitted from the transported statistics predicts without domain identity. On 3DO, WiMANS, and Widar3.0, WiMoT reaches average final accuracies of 94.02%, 89.61%, and 95.16% with at most 0.58 percentage points (pp) of forgetting. On 3DO and Widar3.0 it is 3.77 and 13.11 pp ahead of the strongest of 21 baselines, which uses replay; on WiMANS it matches the strongest replay baseline in accuracy while reducing forgetting from 2.78 to 0.00 pp. Rank-32 covariance factors shrink the moment memory to 6.4% at a cost of at most 0.49 pp.

cs.AI

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2610.06959

Nearly optimal Personalized PageRank computation

Rong-Hua Li, Quanqing Xu, Yichun Yang, Junjie Zhou

原文摘要

We study the fundamental problem of computing Personalized PageRank (PPR) on an undirected and unweighted graph $G$. We focus on the $\eps$-error guarantee introduced by Andersen, Chung, and Lang [ACL; FOCS 2006 $\&$ Internet Math 2007]. Their classic local push method computes an approximate PPR vector satisfying the ACL $\eps$-error guarantee in $O((α\eps)^{-1})$ time, where $α$ is the teleportation parameter. This problem has a lower bound $Ω(\eps^{-1})$. Working with idealized SDDM solves, we eliminate the dependence on $α$ and present an algorithm that achieves the same error guarantee in $O(\eps^{-1-o(1)})$ time. Consequently, we obtain a nearly optimal algorithm for PPR computation under the ACL error guarantee, and a nearly linear algorithm for local graph clustering with complexity independent of $φ$.

cs.DS · cs.CC

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.39151

STRATA: Reinforcement-driven Active Sampling with Tri-paradigm Adaptation for Efficient 3D Spatial Transcriptomics

Junchao Zhu, Ruining Deng, Chongyu Qu, Zhengyi Lu, Yanfan Zhu, Yuechen Yang, Yu Wang, Shilin Zhao 等 10 位作者

原文摘要

Spatial transcriptomics (ST) enables joint characterization of tissue morphology and gene expression. However, 3D volumetric ST acquisition remains expensive. AI-driven methods offer a low-cost alternative but remain limited in accuracy, while recent 2D section-wise ST acquisition still rely on dense grid sampling, resulting in redundant measurements and undersampling of biologically informative regions. To bridge the gap, we propose STRATA, a reinforcement-driven active sampling framework with tri-paradigm adaptation for reconstructing dense 3D transcriptomic maps from sparse voxel-wise ST acquisition. STRATA constructs a 3D graph integrating H&E morphology with single-cell priors and employs a reinforcement learning agent to estimate morphological sparsity and transcriptomic informativeness, enabling budget-aware selection of informative spots. Given these sparse measurements, an adaptive tri-paradigm predictor combines retrieval, regression, and cross-layer imputation through lightweight fusion, dynamically weighting their contributions. Experiments across datasets demonstrate improved sampling efficiency and accuracy, particularly under low-budget settings. Code is available at https://github.com/Junchao-Zhu/STRATA.

cs.CV

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arXiv ↗PDF ↗
首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1172ACL Anthology · ACL 2026

Learning to Think on Hypergraph: HyperCoT for Structure-Guided N-ary Knowledge Graph Completion

Mengxue Yang, Jinming Li, Chun Yang, Jiaqi Zhu Institute of Software, Chinese Academy of Sciences, Jiafan Li, Guanhua Zhang Institute of Software Chinese Academy of Sciences, Ying Li University of the Chinese Academy of Sciences

原文摘要

N-ary knowledge graph completion (KGC) aims to infer missing components in facts with multiple entities under distinct semantic roles, commonly formulated as a knowledge hypergraph link prediction task. Most embedding-based approaches score individual hyperedges relying on enriched structural representations, but overlook intermediate propagation states containing complementary local and global structural evidence. Despite their capability to generate chain-of-thought (CoT) representations for the classical KGC task, large language models (LLMs) struggle with hypergraph structure involving multiple facts, while current hypergraph QA methods only provide LLMs with a single query signal rather than path-level evidence. These limitations hinder the transferability of existing methods, especially those leveraging LLMs, to solve the knowledge hypergraph link prediction problem. To bridge this gap, we propose HyperCoT, a structure-aware approach that models multi-hop structural reasoning as a depth-sensitive progressive evidence accumulation process. It constructs a Graphical Chain-of-Thought (Graph-CoT) by aggregating role-aware hyperedge states along strongly correlated reasoning paths, and injects the resulting path-level structural evidence into each token in query and candidate entities to prompt LLMs. Experiments on three real-world datasets demonstrate that HyperCoT consistently outperforms strong n-ary KGC baselines, particularly in high arity and structural sparsity scenarios, meanwhile yielding interpretable multi-hop reasoning traces.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1704ACL Anthology · ACL 2026

Joint Knowledge Base Completion and Question Answering by Combining Large Language Models and Small Language Models

Yinan Liu Northeastern University, Dongying Lin, Sigang Luo, Xiaochun Yang, Bin Wang

原文摘要

Knowledge Bases (KBs) play a key role in various applications. As two representative KB-related tasks, knowledge base completion (KBC) and knowledge base question answering (KBQA) are closely related and inherently complementary with each other. Thus, it will be beneficial to solve the task of joint KBC and KBQA to make them reinforce each other. However, existing studies usually rely on the small language model (SLM) to enhance them jointly, and the large language model (LLM)’s strong reasoning ability is ignored. In this paper, by combining the strengths of the LLM with the SLM, we propose a novel framework JCQL, which can make these two tasks enhance each other in an iterative manner. To make KBC enhance KBQA, we augment the LLM agent-based KBQA model’s reasoning paths by incorporating an SLM-trained KBC model as an action of the agent, alleviating the LLM’s hallucination and high computational costs issue in KBQA. To make KBQA enhance KBC, we incrementally fine-tune the KBC model by leveraging KBQA’s reasoning paths as its supplementary training data, improving the ability of the SLM in KBC. Extensive experiments over two public benchmark data sets demonstrate that JCQL surpasses all baselines for both KBC and KBQA tasks.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表