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版本更新 · v2arXiv:2511.09895

SE-Diff: Simulator and Experience Enhanced Diffusion Model for Comprehensive ECG Generation

Xiaoda Wang, Kaiqiao Han, Yuhao Xu, Xiao Luo, Yizhou Sun, Wei Wang, Carl Yang

原文摘要

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Electrocardiograms (ECGs) are the most widely used non-invasive tool for cardiac assessment, yet large, well-annotated ECG corpora are scarce due to cost, privacy, and workflow constraints. Generating ECGs can be beneficial for the mechanistic understanding of cardiac electrical activity, enable the construction of large, heterogeneous, and unbiased datasets, and facilitate privacy-preserving data sharing. Generating realistic ECG signals from clinical context is important yet underexplored. Recent work has leveraged diffusion models for text-to-ECG generation, but two challenges remain: (i) existing methods often overlook the physiological simulator knowledge of cardiac activity; and (ii) they ignore broader, experience-based clinical knowledge grounded in real-world practice. To address these gaps, we propose SE-Diff, a novel physiological simulator and experience enhanced diffusion model for comprehensive ECG generation. SE-Diff integrates a lightweight ordinary differential equation (ODE)-based ECG simulator into the diffusion process via a beat decoder and simulator-consistent constraints, injecting mechanistic priors that promote physiologically plausible waveforms. In parallel, we design an LLM-powered experience retrieval-augmented strategy to inject clinical knowledge, providing more guidance for ECG generation. Extensive experiments on real-world ECG datasets demonstrate that SE-Diff improves both signal fidelity and text-ECG semantic alignment over baselines, proving its superiority for text-to-ECG generation. We further show that the simulator-based and experience-based knowledge also benefit downstream ECG classification.

cs.LG · cs.AI

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2605.12541

PPG2ECG: Physiology-Guided Latent Rectified Flow for Electro-Hemodynamic PPG-to-ECG Generation

Xiaoda Wang, Minxiao Wang, Kaiqiao Han, Defu Cao, Ching Chang, Yidan Shi, Runze Yan, Xiao Luo 等 13 位作者

原文摘要

Electrocardiography (ECG) is the clinical standard for cardiac assessment but requires dedicated hardware that does not scale to daily-life monitoring. Photoplethysmography (PPG) is ubiquitous in wearables but lacks ECG-specific diagnostic morphology and is corrupted by motion and sensor noise. PPG-to-ECG generation aims to bridge this gap by recovering electrical morphology and timing from peripheral pulse signals. However, existing methods largely rely on statistical alignment and data-driven generation. They fail to explicitly structure the latent space around physiology-aware electro-hemodynamic factors and lack constraints from forward physiological dynamics. To address these challenges, we propose PPG2ECG, a physiology-guided latent rectified flow framework. PPG2ECG introduces an electro-hemodynamic simulator that co-models ECG and PPG through shared cardiac phase dynamics. Guided by this simulator, a Physiology-Aware AutoEncoder learns a structured electro-hemodynamic latent space. Then we integrate this simulator guidance into a PPG-conditioned latent rectified flow, enforcing ECG-side morphology consistency and ECG-to-PPG forward hemodynamic consistency during generative transport. Experiments on the large-scale MC-MED dataset demonstrate that PPG2ECG significantly improves PPG-to-ECG generation and downstream cardiovascular disease classification, proving its ability to generate ECGs that are both signal-faithful and physiologically plausible under the ECG-to-PPG hemodynamic pathway

eess.SP · cs.AI · cs.LG

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2608.25005

The Imperfective Paradox Is Not Necessarily in Large Language Models: A Benchmark Failure Before a Model Failure

Kaiqiao Han, Katarzyna Pruś, Mark Steedman, Yizhou Sun

原文摘要

Recent work uses an NLI benchmark of the imperfective paradox to argue that large language models exhibit a Teleological Bias and Calibration Crisis. We identify three validity concerns in benchmark construction, including aspectual reduction, semantic bias, and relation bias. Under a strict NLI standard, 76% of the Group A instances do not explicitly rule out culmination; in native-speaker annotation, 38% of Group A and 29% of Group C examples permit an alternative interpretation. To better isolate the semantic contrast, we construct Lexically Matched Minimal Pairs. Moreover, by formulating event-semantic NLI as a multi-step reasoning problem, we evaluate intermediate semantic judgments and use oracle-guided settings. We find that incorrect NLI entailment does not fully support teleological bias. Prompting often changes final NLI decisions without reliably improving the underlying semantic judgments, offering a possible explanation for the Calibration Crisis.

cs.CL · cs.LG

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arXiv ↗PDF ↗
新论文 · v1arXiv:2611.05739

PersonaCodeBench: Evaluating Coding Agents in Persona-driven Human-Interactive Sessions

Haixin Wang, Jianheng Hou, Hongyu Shen, Wenzhe Fan, Wei-Chieh Huang, Qianyu Zhu, Weichen Li, Taoran Li 等 30 位作者

原文摘要

Coding agents must deliver correct software while respecting users' expertise, preferences, and working conditions. Existing benchmarks increasingly incorporate interaction, yet personalized requirement fulfillment remains underexplored. We introduce PersonaCodeBench, which turns user characteristics into verifiable obligations in persona-driven multi-turn coding sessions. Our persona pool spans roles, technical abilities, interaction preferences, and practical constraints, yielding task-grounded evolved requirements for implementation, permissions, testing, explanation, and delivery. At runtime, a controller governs user simulator responses and requirement disclosure, using online requirement evaluation to provide feedback and advance the interaction. Requirements emerge progressively, with their content, disclosure conditions, and acceptance criteria fixed before evaluation. A completion verifier and a personalization verifier separately assess native correctness and persona fulfillment. Joint pass requires both adherence to the declared budget and compliance with validity conditions. We evaluate all major frontier agents, establish a comprehensive leaderboard, and conduct detailed experimental analyses to validate effectiveness. PersonaCodeBench supports reproducible evaluation of coding agents' ability to meet explicit, personalized user expectations alongside coding objectives.

cs.AI

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.37843

Where the Error Lives: Spectral Representations of Learned Kohn-Sham Hamiltonians

Fang Sun, Hekai Cheng, Ruoyan Li, Yuanzhou Chen, Wei Wang, Jason Cong, Yizhou Sun

原文摘要

Kohn-Sham density functional theory (DFT) is the standard method for computing the electronic structure of molecules and materials, but its self-consistent-field (SCF) iterations make it expensive for large systems and high-throughput screening. Machine-learned Hamiltonian models offer a shortcut: an equivariant network predicts the Kohn-Sham Hamiltonian matrix in one forward pass, and diagonalizing the prediction yields orbital energies, the HOMO-LUMO gap, molecular orbitals and the electron density. These models are trained to match the reference matrix entry by entry, yet a small entry-wise error does not guarantee accurate eigenvalues or eigenvectors. Two physics-informed alternatives go partway: a recently proposed wavefunction-alignment loss adds a spectral penalty without diagonalizing the prediction, and matching the electron density of the diagonalized prediction supervises it directly. Neither is complete: by representing the prediction error in the eigenbasis of the reference Hamiltonian, we show that each sees only part of the error, and that shifting the predicted orbital energies leaves the electron density exactly unchanged. The same analysis identifies a complete training signal: the cumulative local density of states (cumulative LDOS), the number of electrons at each point in space with energy below a given threshold. The cumulative LDOS is a single physical observable that contains the electron density as a special case, responds to every component of the error, determines the Hamiltonian uniquely, and yields gradients that do not vanish for large orbitalenergy errors. Fine-tuning three Hamiltonian networks on QH9 in this way, which we call FermiScope, reduces the HOMO-LUMO gap error without increasing the element-wise error. The gains carry over to out-of-distribution and molecular-dynamics splits, where the wavefunction-alignment loss helps less.

physics.chem-ph · cs.AI

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arXiv ↗PDF ↗
首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1339ACL Anthology · ACL 2026

Why Are We Moral? An LLM-based Agent Simulation Approach to the Study of Moral Evolution

Zhou Ziheng, Huacong Tang University of California, Los Angeles, Mingjie Bi Beijing Institute for General Artificial Intelligence, Wanying He Wuhan University, Fang Sun, Yizhou Sun University of California, Los Angeles and Amazon, Ying Nian Wu, Demetri Terzopoulos University of California, Los Angeles 等 10 位作者

原文摘要

The evolution of morality presents a puzzle: natural selection should favor self-interest, yet humans developed moral systems promoting altruism. Traditional approaches must abstract away cognitive processes, leaving open how cognitive factors shape moral evolution. We introduce an LLM-based agent simulation framework that brings cognitive realism to this question: agents with varying moral dispositions perceive, remember, reason, and decide in a simulated prehistoric hunter-gatherer society. This enables us to manipulate factors that traditional models cannot represent—such as moral type observability and communication bandwidth—and to discover emergent cognitive mechanisms from agent interactions. Across 20 runs spanning four settings, we find that cooperation and mutual help are the central driver of evolutionary survival, with universal and reciprocal morality exhibiting the most stable outcomes across conditions while selfishness is strongly disfavoured. Beyond cooperation itself, we further identify cognition as a central mediator—most clearly through a cost of moral judgment that shifts the winning moral type across settings, with a self-purging effect among selfish agents as an additional cognitive pattern. We validate robustness across multiple LLM backbones, architecture ablations, and prompt sensitivity analyses. This work establishes LLM-based simulation as a powerful new paradigm to complement traditional research in evolutionary biology and anthropology, opening new avenues for investigating the complexities of moral and social evolution.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1764ACL Anthology · ACL 2026

Dynamic Generation of Multi LLM Agents Communication Topologies with Graph Diffusion Models

Eric Hanchen Jiang, Levina Li, Frank Wan, Xiao Liang, Sophia Yin, Yuchen Wu University of Washington, Xinfeng Li Nanyang Technological University, Yizhou Sun University of California, Los Angeles and Amazon 等 11 位作者

原文摘要

The efficiency of multi-agent systems driven by large language models (LLMs) largely hinges on their communication topology. However, designing an optimal topology is a non-trivial challenge, as it requires balancing competing objectives such as task performance, communication cost, and robustness. Existing frameworks often rely on static or hand-crafted topologies, which inherently fail to adapt to diverse task requirements, leading to either excessive token consumption for simple problems or performance bottlenecks for complex ones. To address this challenge, we introduce a novel generative framework called Guided Topology Diffusion (GTD). Inspired by conditional discrete graph diffusion models, GTD formulates topology synthesis as an iterative construction process. At each step, the generation is steered by a lightweight proxy model that predicts multi-objective rewards (e.g., accuracy, utility, cost), enabling real-time, gradient-free optimization towards task-adaptive topologies. This iterative, guided synthesis process distinguishes GTD from single-step generative frameworks, enabling it to better navigate complex design trade-offs. We validated GTD across multiple benchmarks, and experiments show that this framework can generate highly task-adaptive, sparse, and efficient communication topologies, significantly outperforming existing methods in LLM agent collaboration. Our code is available at https://anonymous.4open.science/r/diffusion_agent-953C.

cs.CL · cs.MA

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表