让下一篇重要论文，不再错过。

We study context-aware time-series forecasting, in which a single target variable is predicted from its own history and a set of contextual variables, such as weather and calendar information. As the context becomes more diverse, a single model struggles to capture all of its regimes, while ensemble learning and Mixture-of-Experts approaches rely on manual data partitioning or soft routing, which increases the inference cost and hinders interpretability. We propose CATF, a Context-Aware Time-Series Forecasting framework built on a Manager-Worker architecture: a Transformer-based Manager routes each input to a single Worker based on the context, using hard routing during both training and inference. The Workers thus specialize without manual data partitioning, and any single-model forecaster can serve as a Worker. On five context-rich datasets, four horizons, and two normalization schemes, CATF improves over its standalone counterpart in 162 of 200 comparisons, the best CATF-enhanced model outperforms the best standalone baseline in 19 of 20 settings, and it outperforms the zero-shot Time-MoE foundation model in 15 of 20 settings. A case study on bike-sharing data shows that the Manager routes inputs by the calendar and that each Worker specializes in a different weekly pattern.

Unified Multimodal Models (UMMs) integrate visual understanding, generation, and editing within a single unified framework. However, existing unified multimodal datasets and benchmarks remain dominated by single-turn tasks. Even in recent multi-turn datasets, many turns can be solved independently without tracking information across turns. Consequently, they provide limited supervision and evaluation for multimodal stateful interaction, which requires models to understand, maintain, update, and faithfully realize evolving dialogue states across turns. To address this gap, we introduce YANAMI, the first large-scale multimodal dialogue dataset and benchmark for stateful interaction, comprising YANAMI-400K and YANAMI-Bench. YANAMI-400K contains 400K multi-turn multimodal dialogues, with more than 2M images and 2.6M dialogue turns. The dialogues span four representative scenarios: Multi-Image Fusion, Image Editing, World Modeling, and Visual Reasoning, and require models to continuously track, preserve, and revise evolving multimodal dialogue states across turns. YANAMI-Bench comprises 400 multi-turn dialogues for systematically evaluating multimodal stateful interaction. It jointly evaluates Dialogue State Understanding and Visual Realization, characterizing the gap between models' ability to understand evolving dialogue states and their ability to faithfully realize them in visual outputs. Experiments show that fine-tuning BAGEL on YANAMI-400K improves image editing, generation, and multimodal stateful interaction by 10.3%, 2.0%, and 13.23%, respectively, while preserving its general visual understanding capabilities. Evaluations on YANAMI-Bench further reveal that existing UMMs still struggle to maintain, update, and visually realize evolving multimodal dialogue states.

Antibody affinity maturation is a natural optimization process in which B cells acquire mutations through somatic hypermutation (SHM), undergo selection for improved antigen binding, and iteratively evolve toward higher affinity. Computationally modeling this process requires capturing both biologically plausible mutations and antigen-specific selection. However, existing mutation models do not directly optimize binding, while affinity optimization often neglects realistic mutation trajectories. We introduce iGC (in silico Germinal Centers), a two-stage reinforcement learning (RL) framework for antigen-specific antibody optimization. Stage 1 learns an SHM mutation prior from parent-child pairs in B-cell lineage trees and adapts it to a target affinity-maturation dataset. Stage 2 initializes an RL policy from this prior and optimizes antigen binding with Kullback-Leibler (KL) regularization toward the frozen prior. To prevent reward exploitation, including repetitive high-reward substitutions and structurally tolerated framework mutations, we introduce a Reward-Tax Meta-Gradient objective. RewardNet smooths the affinity landscape, while TaxNet penalizes reward overexploitation, jointly defining a learned meta-reward for policy optimization. We evaluate iGC on mutation prediction, SHM consistency, affinity optimization, and mutation diversity. The mutation prior more than doubles the strongest baseline in mutation-site prediction. Following RL optimization, iGC maintains SHM sequence structure. It also achieves a strong exploration-exploitation balance, yielding competitive reward-diversity products across candidate-selection cutoffs. These results demonstrate that iGC integrates biologically plausible mutation generation with antigen-specific affinity selection, providing an in silico framework for iterative antibody affinity maturation.